Mothers of infants with the acquired immunodeficiency syndrome. Evidence for both symptomatic and asymptomatic carriers
Mothers of infants with the acquired immunodeficiency syndrome. Evidence for both symptomatic and asymptomatic carriers
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患有获得性免疫缺陷综合症婴儿的母亲。
DOI：
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发表时间：
1985
期刊：
影响因子：
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通讯作者：
W. Parks
中科院分区：
文献类型：
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作者：
G. Scott;M. Fischl;N. Klimas;M. Fletcher;G. Dickinson;R. Levine;W. Parks
对22名患有获得性免疫缺陷综合征(AIDS)或艾滋病相关综合征的婴儿的16名母亲进行了随访，以寻找临床和免疫异常的证据。除了一个例外，所有母亲在分娩时临床情况良好，但有免疫功能障碍的证据，T细胞异常，T4/T8比率倒置和/或血清免疫球蛋白水平升高，特别是免疫球蛋白。在平均30个月的随访期内，5名母亲患上了艾滋病，7名母亲患上了与艾滋病有关的复合症。11名母亲随后的12次怀孕产生了4名受影响的婴儿，这表明母亲可能会持续感染。6名母亲接生了随后出生的婴儿，这些婴儿仍未受到影响。这些结果表明，母亲可能是非输血相关性艾滋病病例或婴儿艾滋病相关复合体的感染源，母亲有持续性的免疫异常，她们患艾滋病或艾滋病相关复合体的风险增加。(JAMA 1985；253：363-366)
Sixteen mothers of 22 infants with the acquired immunodeficiency syndrome (AIDS) or AIDS-related complex were followed up for evidence of clinical and immunologic abnormalities. With one exception, all mothers were clinically well at delivery but had evidence of immune dysfunction, with T-cell abnormalities and inverted T4/T8 ratios and/or elevation of serum immunoglobulin levels, particularly of IgG. During a follow-up period that averaged 30 months, AIDS developed in five of the mothers and AIDS-related complex in seven. Twelve subsequent pregnancies in 11 mothers produced four affected infants, suggesting that mothers can be persistently infected. Six mothers were delivered of subsequent infants who remain unaffected. These results suggest that the mothers are the likely source of infection in non—transfusion-associated cases of AIDS or AIDS-related complex in infants, that mothers have persistent immunologic abnormalities, and that they are at increased risk of developing AIDS or AIDS-related complex. ( JAMA 1985;253:363-366)
性乱和吸毒成瘾的母亲所生婴儿患有 T4/T8 比例逆转的获得性免疫缺陷。
DOI：
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发表时间：
1983
期刊：
JAMA : the journal of the American Medical Association
影响因子：
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作者：
Rubinstein,A;Sicklick,M;Gupta,A;Bernstein,L;Klein,N;Rubinstein,E;Spigland,I;Fruchter,L;Litman,N;Lee,H;Hollander,M
通讯作者：
Hollander,M
获得性免疫缺陷综合征的母婴传播。
影响因子：
8
作者：
Cowan,MJ;Hellmann,D;Chudwin,D;Wara,DW;Chang,RS;Ammann,AJ
通讯作者：
Ammann,AJ