Redox and Near-Infrared Light-Responsive Nanoplatform for Enhanced Pesticide Delivery and Pest Control in Rice: Construction, Efficacy, and Potential Mechanisms.
Redox and Near-Infrared Light-Responsive Nanoplatform for Enhanced Pesticide Delivery and Pest Control in Rice: Construction, Efficacy, and Potential Mechanisms.
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DOI：
10.1021/acsami.3c08413
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发表时间：
2023-08
影响因子：
9.5
通讯作者：
Mao Zong;Chang Yu;Jia-Qiao Li;Dan Sun;Jiayin Wang;Z. Mo;Chuwei Qin;Disi Yang;Zhaoyang Zhang;Q. Zeng;Chengyue Li;Kangsheng Ma;H. Wan;Jianhong Li;Shun He
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文献类型：
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作者：
Mao Zong;Chang Yu;Jia-Qiao Li;Dan Sun;Jiayin Wang;Z. Mo;Chuwei Qin;Disi Yang;Zhaoyang Zhang;Q. Zeng;Chengyue Li;Kangsheng Ma;H. Wan;Jianhong Li;Shun He
褐飞虱（Nilaparvata lugens（Stål））是亚洲各国的主要水稻害虫，对水稻产量和品质造成严重的负面影响。在这项研究中，我们开发了一种新的纳米平台（NIT@MON@CuS）的农药输送，响应氧化还原和近红外光刺激。纳米平台由CuS纳米颗粒与介孔有机二氧化硅（MON）组成，负载烯啶虫胺（NIT）。NIT@MON@CuS的平均粒径为190 nm，负载效率为22%，在近红外区域表现出显著的热响应，表现出优异的光热转换能力和稳定性。体外释放动力学研究表明，烯啶虫胺在近红外光和谷胱甘肽条件下快速释放，有利于令人满意的温度升高和加速药物释放。NIT@MON@ CuS处理组的N.褐飞虱，96 h后与烯啶虫胺处理组相比从62%增加到88%。生物测定结果表明，NIT@MON@CuS显著增强烯啶虫胺对实验室和田间耐药菌株的毒力，提高幅度超过1.4倍。lugens。RT-qPCR结果表明，MON@CuS能够降低P450基因的表达，从而提高N.杀虫剂的替代品这些发现表明，MON@CuS作为智能害虫控制平台具有巨大潜力，可提供可持续和有效的方法来保护作物免受害虫的侵害。
The brown planthopper, Nilaparvata lugens (Stål), is a major rice pest in various Asian countries, causing significant negative impacts on rice yield and quality. In this study, we developed a novel nanoplatform (NIT@MON@CuS) for pesticide delivery that responds to redox and near-infrared light stimuli. The nanoplatform consisted of CuS nanoparticles with mesoporous organic silica (MON), loaded with nitenpyram (NIT). With an average size of 190 nm and a loading efficiency of 22%, NIT@MON@CuS exhibited remarkable thermal response in the near-infrared region, demonstrating excellent photothermal conversion ability and stability. In vitro release kinetics demonstrated the rapid release of nitenpyram under near-infrared light and glutathione conditions, facilitating a satisfactory temperature increase and accelerated drug release. The NIT@MON@CuS-treated group exhibited a higher mortality of N. lugens, increasing from 62 to 88% compared to the group treated with nitenpyram technical after 96 h. Bioassay revealed that NIT@MON@CuS significantly enhanced nitenpyram toxicity by more than 1.4-fold against both laboratory insecticide-resistant and field strains of N. lugens. Furthermore, RT-qPCR results demonstrated that MON@CuS had the capability to reduce P450 gene expression, thereby improving the sensitivity of N. lugens to insecticides. These findings suggest that MON@CuS holds great potential as an intelligent pest control platform, offering a sustainable and efficient approach to protect crops against pests.