EPIDEMIOLOGY OF CERCOPITHECINE HERPESVIRUS-1 (B-VIRUS) INFECTION AND SHEDDING IN A LARGE BREEDING COHORT OF RHESUS MACAQUES
EPIDEMIOLOGY OF CERCOPITHECINE HERPESVIRUS-1 (B-VIRUS) INFECTION AND SHEDDING IN A LARGE BREEDING COHORT OF RHESUS MACAQUES
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DOI：
10.1093/infdis/167.2.257
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发表时间：
1993-02-01
影响因子：
6.4
通讯作者：
SCOTT, LM
中科院分区：
文献类型：
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作者：
WEIGLER, BJ;HIRD, DW;SCOTT, LM
从1989年9月至1991年1月，通过一系列体格检查、行为亚组研究（n = 51）和重复诊断试验，对加州地区灵长类动物研究中心的一个大型（n = 157）恒河猴队列中B病毒感染的流行病学进行了前瞻性评价。基线时半数患者为B病毒抗体阳性;随后，通过单独的血清学（42例）或病毒分离（5例）记录感染事件。观察到8例复发感染和1例有症状（原发）病例。随着猴子年龄的增长，B病毒感染的风险增加，很少有>3岁的猴子未被感染。青春期后的猴子和那些进入性青春期（2-3年）的风险最大，虽然受伤的笼和繁殖历史（女性）都是显着的预测时间感染。B病毒以相等比例从口腔或结膜和生殖器组织中分离。传播只发生在繁殖季节，可能与人口中社会压力因素的升高相吻合。
The epidemiology of B virus infection in a large (n = 157) cohort of rhesus macaques at the California Regional Primate Research Center was evaluated prospectively from September 1989 through January 1991 by serial physical examinations, a behavioral substudy (n = 51), and repeated diagnostic testing. Half were B virus antibody-positive at baseline; subsequently, incident cases of infection were documented through serology alone (42) or with virus isolation (5). Eight recurrent infections and a single symptomatic (primary) case were observed. Risk of B virus infection increased as monkeys aged, with few >3 years old remaining uninfected. Postpubertal monkeys and those entering sexual adolescence (2-3 years) were at greatest risk, although wounding by cagemates and breeding history (for females) were both significant predictors of time to infection. B virus was isolated from oral or conjunctival and genital tissues in equal proportions. Transmission occurred only during the breeding season, possibly coinciding with an elevation in social stressors in the population.