The role of surgery and ablative radiotherapy in oligometastatic breast cancer.
The role of surgery and ablative radiotherapy in oligometastatic breast cancer.
复制标题
手术和消融放疗在寡转移乳腺癌中的作用。
作者：
J. Salama;S. Chmura
提供精确聚焦放射的能力，结合改进的手术技术，导致了多例寡转移性乳腺癌患者长期存活的报告。已知转移灶的切除或消融（通常在全身治疗方案后出现）有可能改变范式，使许多患者没有疾病证据。然而，这些疗法的效用尚未在III期研究中得到证实。此外，转移导向治疗的患者选择基于临床标准，许多患者无法从这些治疗中获益。放射技术的改进仍在继续，新的发现正在揭示患者中处于寡转移状态的乳腺癌的生物学。整合到正在进行的研究和开发中，它们有可能改变寡转移患者的标准管理策略。
The ability to deliver precise focused radiation, combined with improved surgical techniques, has led to multiple reports of long-term survivors in patients with oligometastatic breast cancer. The removal or ablation of known metastases, often present after systemic therapy regimens has the potential to be paradigm shifting rendering many patients without evidence of disease. However, the utility of these therapies has not been proven in phase III studies. Additionally, patient selection for metastasis-directed therapies is based on clinical criteria, with many patients not benefiting from these therapies. Refinements of radiation techniques are continuing, and discoveries are uncovering the biology of breast cancer in the oligometastatic state among patients. Integrated into ongoing studies, and those in development, they have the potential to alter standard management strategies in oligometastatic patients.
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影响因子：
5.2
作者：
N. Mehta;A. Mauer;S. Hellman;D. Haraf;E. Cohen;E. Vokes;R. Weichselbaum
通讯作者：
N. Mehta;A. Mauer;S. Hellman;D. Haraf;E. Cohen;E. Vokes;R. Weichselbaum
影响因子：
9
作者：
Fong, Y;Fortner, J;Blumgart, LH
通讯作者：
Blumgart, LH
影响因子：
45.3
作者：
Kocher, Martin;Soffietti, Riccardo;Mueller, Rolf-Peter
通讯作者：
Mueller, Rolf-Peter
影响因子：
45.3
作者：
Sledge, GW;Neuberg, D;Wood, WC
通讯作者：
Wood, WC