Shaping cups into phagosomes and macropinosomes.
Shaping cups into phagosomes and macropinosomes.
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DOI:
10.1038/nrm2447
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发表时间:
2008-08
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影响因子:
--
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中科院分区:
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--
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The ingestion of particles or cells by phagocytosis and of fluids by macropinocytosis requires the formation of large endocytic vacuolar compartments inside cells by the organized movements of membranes and the actin cytoskeleton. Fc receptor-mediated phagocytosis is guided by zipper-like progression of local, receptor-initiated responses that conform to particle geometry. In contrast, macropinosomes and some phagosomes form with little or no guidance from receptors. The common organizing structure is the cup-shaped invagination of plasma membrane that becomes the phagosome or macropinosome. Recent studies indicate a feedback regulation of signal transduction based on the physical properties of forming cups.
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