Interaction of chemical and high vascular pressure injury in isolated canine lung.
Interaction of chemical and high vascular pressure injury in isolated canine lung.
复制标题
离体犬肺化学损伤和高血管压力损伤的相互作用。
DOI：
10.1152/jappl.1990.69.5.1657
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
Song,W
中科院分区：
文献类型：
--
作者：
Townsley,MI;Lim,EH;Sahawneh,TM;Song,W
由于对肺部的化学和机械损伤可能与创伤同时发生，因此我们假设在对肺部进行化学损伤后，血管压力引起的（机械）损伤的压力阈值会降低。正常离体犬肺叶 (N, n = 14) 和因气道酸滴注 (AAI, n = 18) 或血管内油酸 (OA, n = 25) 损伤的犬肺叶暴露于 19 至 130 cmH2O 范围内的短时（5 分钟）静脉压升高 (HiPv)。在 HiPv 应力之前，毛细管过滤系数 (Kf,c) 为 0.12 +/- 0.01、0.27 +/- 0.03 和 0.31 +/- 0.02 ml.min-1.cmH2O-1 x 100 g-1，等重毛细管压力 (Pc,i) 为 9.2 +/- 0.3、6.8 +/- 0.5， N、AAI 和 OA 肺中分别为 6.5 +/- 0.3 cmH2O。然而，所有组对 HiPv 的反应模式相似：当峰值静脉压 (Pv) 保持低于 55 cmH2O 时，Kf,c 与 HiPv 前的值没有差异，但当峰值 Pv 超过 55 cmH2O 时，Kf,c 可逆性增加（P 小于 0.05）。压力暴露后测得的总蛋白反射系数（西格玛）对于 N、AAI 和 OA 叶的平均值分别为 0.60 +/- 0.03、0.32 +/- 0.04 和 0.37 +/- 0.09。然而，与高压下发生孔隙拉伸时预期的结果相反，在所有组中，当 Pv 超过 55 cmH2O 时，在 HiPv 应力期间测量的 sigma 显着大于恢复期间测量的值。（摘要截断为 250 字）
Because both chemical and mechanical insults to the lung may occur concomitantly with trauma, we hypothesized that the pressure threshold for vascular pressure-induced (mechanical) injury would be decreased after a chemical insult to the lung. Normal isolated canine lung lobes (N, n = 14) and those injured with either airway acid instillation (AAI, n = 18) or intravascular oleic acid (OA, n = 25) were exposed to short (5-min) periods of elevated venous pressure (HiPv) ranging from 19 to 130 cmH2O. Before the HiPv stress, the capillary filtration coefficient (Kf,c) was 0.12 +/- 0.01, 0.27 +/- 0.03, and 0.31 +/- 0.02 ml.min-1.cmH2O-1 x 100 g-1 and the isogravimetric capillary pressure (Pc,i) was 9.2 +/- 0.3, 6.8 +/- 0.5, and 6.5 +/- 0.3 cmH2O in N, AAI, and OA lungs, respectively. However, the pattern of response to HiPv was similar in all groups: Kf,c was no different from the pre-HiPv value when the peak venous pressure (Pv) remained less than 55 cmH2O, but it increased reversibly when peak Pv exceeded 55 cmH2O (P less than 0.05). The reflection coefficient (sigma) for total proteins measured after pressure exposure averaged 0.60 +/- 0.03, 0.32 +/- 0.04, and 0.37 +/- 0.09 for N, AAI, and OA lobes respectively. However, in contrast to the result expected if pore stretching had occurred at high pressure, in all groups the sigma measured during the HiPv stress when Pv exceeded 55 cmH2O was significantly larger than that measured during the recovery period.(ABSTRACT TRUNCATED AT 250 WORDS)