Combinatorial Approaches for Efficient Design of Photoswitchable Protein-Protein Interactions as In Vivo Actuators.
Combinatorial Approaches for Efficient Design of Photoswitchable Protein-Protein Interactions as In Vivo Actuators.
复制标题
在活体致动器中有效设计光切换蛋白质-蛋白质相互作用的组合方法。
DOI：
10.3389/fbioe.2022.844405
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发表时间：
2022
影响因子：
5.7
通讯作者：
Gu L
中科院分区：
文献类型：
--
作者：
Zhang X;Pan Y;Kang S;Gu L
可转换的两组分蛋白二聚体系统在过去20年中提供了多功能性的操纵和解剖。和限制，我们的目标是确定可以解决当前工程挑战并扩大体内应用程序的新机会。
Light switchable two-component protein dimerization systems offer versatile manipulation and dissection of cellular events in living systems. Over the past 20 years, the field has been driven by the discovery of photoreceptor-based interaction systems, the engineering of light-actuatable binder proteins, and the development of photoactivatable compounds as dimerization inducers. This perspective is to categorize mechanisms and design approaches of these dimerization systems, compare their advantages and limitations, and bridge them to emerging applications. Our goal is to identify new opportunities in combinatorial protein design that can address current engineering challenges and expand in vivo applications.
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影响因子：
48
作者：
Kennedy, Matthew J.;Hughes, Robert M.;Peteya, Leslie A.;Schwartz, Joel W.;Ehlers, Michael D.;Tucker, Chandra L.
通讯作者：
Tucker, Chandra L.
影响因子：
48
作者：
Fowler, Douglas M.;Fields, Stanley
通讯作者：
Fields, Stanley
影响因子：
16.6
作者：
Guo Z;Smutok O;Johnston WA;Walden P;Ungerer JPJ;Peat TS;Newman J;Parker J;Nebl T;Hepburn C;Melman A;Suderman RJ;Katz E;Alexandrov K
通讯作者：
Alexandrov K
影响因子：
4.7
作者：
Huang Z;Li Z;Zhang X;Kang S;Dong R;Sun L;Fu X;Vaisar D;Watanabe K;Gu L
通讯作者：
Gu L
影响因子：
14.8
作者：
Hill, Zachary B.;Martinko, Alexander J.;Wells, James A.
通讯作者：
Wells, James A.