Clinical efficacy of the co-administration of Turmeric and Black seeds (Kalongi) in metabolic syndrome - A double blind randomized controlled trial - TAK-MetS trial
Clinical efficacy of the co-administration of Turmeric and Black seeds (Kalongi) in metabolic syndrome - A double blind randomized controlled trial - TAK-MetS trial
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DOI：
10.1016/j.ctim.2015.01.008
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发表时间：
2015-04-01
影响因子：
3.6
通讯作者：
Gilani, A. H.
中科院分区：
文献类型：
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作者：
Amin, F.;Istam, N.;Gilani, A. H.
目的：为了比较黑籽和姜黄单独使用和低剂量联合使用在代谢综合征（MetS）患者中的临床疗效。设计：双盲随机对照试验。设置：Hijrat殖民地，卡拉奇，巴基斯坦。干预：表面健康的男性（n=250），谁筛选阳性MetS，被随机分配到黑色种子，（1.5g/天）、姜黄（2.4g/天）、其组合（900 mg黑籽和1.5g姜黄/天）或安慰剂持续8周。主要观察指标：体重指数（BMI）、体脂百分比（BF%）、腰围（WC）、臀围（HC）、血压（BP）、血脂（胆固醇、HDL-胆固醇、LDL-胆固醇和TG）、空腹血糖（FBG）和C-反应蛋白（CRP）。WC和BF%。与安慰剂相比，联合用药改善了除HDL-胆固醇外的所有参数，并降低了FBG和LDL-胆固醇。在第8周，与安慰剂相比，黑籽降低了血脂和FBG，而姜黄降低了LDL-胆固醇和CRP。有趣的是，具有60%剂量的单个草药的组合组显示出所有参数从基线的改善。与安慰剂相比，它降低了BF%、空腹血糖、胆固醇、TG、低密度脂蛋白胆固醇、C反应蛋白，并提高了高密度脂蛋白胆固醇。结论：当姜黄和黑籽以单独草药剂量的60%联合给药时，代谢综合征的所有参数均得到改善，功效增强，不良反应可忽略不计。因此，黑籽和姜黄的组合可以建议与生活方式的改变作为MetS患者的起点，以阻止其未来的并发症和进展。(C)2015爱思唯尔有限公司版权所有。
Objective: To compare the clinical efficacy of Black seeds and Turmeric alone and its co-administration in lower doses among patients with metabolic syndrome (MetS).Design: Double-blind-randomized-controlled trial.Setting: Hijrat colony, Karachi, Pakistan.Intervention: Apparently healthy males (n=250), who screened positive for MetS, were randomized to either Black seeds (1.5g/day), Turmeric (2.4g/day), its combination (900 mg Black seeds and 1.5 g Turmeric/day) or placebo for 8 weeks. Main outcome measures: body-mass-index (BMI), body-fat-percent (BF%), waist-circumference (WC), hip-circumference (HC), blood pressure (BP), lipid-profile (cholesterol, HDL-cholesterol, LDL-cholesterol and TG), fasting blood glucose (FBG) and c-reactive protein (CRP).Results: At 4 weeks, compared to baseline, Black seed and Turmeric alone showed improvement in BM!, WC and BF%. Combination improved all parameters except HDL-cholesterol with lower FBG and LDL-cholesterol as compared to placebo. At 8 weeks, compared to placebo, Black seeds reduced lipids and FBG, while Turmeric reduced LDL-cholesterol and CRP. Interestingly, combination group with 60% dose of the individual herbs showed an improvement in all parameters from baseline. When compared to placebo, it reduced BF%, FBG, cholesterol, TG, LDL-cholesterol, CRP and raised HDL-cholesterol.Conclusion: Turmeric and Black seeds showed improvement in all parameters of metabolic syndrome, when co-administered at 60% of doses of individual herbs with enhanced efficacy and negligible adverse-effects. The combination of Black seeds and Turmeric can therefore, be recommended with lifestyle modification as a starting point for patients with MetS to halt its future complications and progression. (C) 2015 Elsevier Ltd. All rights reserved.