The association between hypertensive arteriopathy and cerebral amyloid angiopathy in spontaneously hypertensive stroke-prone rats.
The association between hypertensive arteriopathy and cerebral amyloid angiopathy in spontaneously hypertensive stroke-prone rats.
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DOI：
10.1111/bpa.12629
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发表时间：
2018-11
期刊：
影响因子：
--
通讯作者：
Schreiber S
中科院分区：
文献类型：
--
作者：
Jandke S;Garz C;Schwanke D;Sendtner M;Heinze HJ;Carare RO;Schreiber S
我们的目的是检验以下假设：在自发性高血压卒中易感大鼠（SHRSP）中，非淀粉样脑小血管疾病/高血压动脉病（HA）导致血管壁损伤，可能促进脑淀粉样血管病（CAA）。我们的研究包括21只雄性SHRSP（17-44周龄）和10只年龄和性别匹配的Wistar对照大鼠，使用甲氧基-X 04、右旋糖酐和脑血流量（CBF）测量对顶叶皮质中的小动脉进行双光子（2PM）成像。我们的数据表明，SHRSP中的HA以时间和年龄依赖性方式进展，从小血管壁损伤（1A期）开始，进行到CBF减少（1B期），非闭塞性（2期），最后闭塞性血栓（3期）。Wistar动物也表现出小的血管壁损伤，但没有任何后期HA阶段。近一半的SHRSP还显示血管甲氧基-X 04阳性，提示皮质CAA。在以血栓性闭塞（2期或3期）为特征的小血管中发现血管β淀粉样蛋白沉积。大鼠大脑的尸检分析证实了活体2PM显微镜检查的结果。因此，我们的数据总体上表明，晚期HA可能在CAA发展中发挥作用，两种小血管疾病实体可能与衰老大脑的相同病理谱相关。
We aimed to test the hypothesis that in spontaneously hypertensive stroke‐prone rats (SHRSP), non‐amyloid cerebral small vessel disease/hypertensive arteriopathy (HA) results in vessel wall injury that may promote cerebral amyloid angiopathy (CAA). Our study comprised 21 male SHRSP (age 17–44 weeks) and 10 age‐ and sex‐matched Wistar control rats, that underwent two‐photon (2PM) imaging of the arterioles in the parietal cortex using Methoxy‐X04, Dextran and cerebral blood flow (CBF) measurements. Our data suggest that HA in SHRSP progresses in a temporal and age‐dependent manner, starting from small vessel wall damage (stage 1A), proceeding to CBF reduction (stage 1B), non‐occlusive (stage 2), and finally, occlusive thrombi (stage 3). Wistar animals also demonstrated small vessel wall damage, but were free of any of the later HA stages. Nearly half of all SHRSP additionally displayed vascular Methoxy‐X04 positivity indicative of cortical CAA. Vascular β‐amyloid deposits were found in small vessels characterized by thrombotic occlusions (stage 2 or 3). Post‐mortem analysis of the rat brains confirmed the findings derived from intravital 2PM microscopy. Our data thus overall suggest that advanced HA may play a role in CAA development with the two small vessel disease entities might be related to the same pathological spectrum of the aging brain.
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影响因子：
12.7
作者：
Grinberg LT;Thal DR
通讯作者：
Thal DR
影响因子：
1.2
作者：
Drew PJ;Blinder P;Cauwenberghs G;Shih AY;Kleinfeld D
通讯作者：
Kleinfeld D
影响因子：
5.3
作者：
Bueche, Celine Z.;Hawkes, Cheryl;Garz, Cornelia;Vielhaber, Stefan;Attems, Johannes;Knight, Robert T.;Reymann, Klaus;Heinze, Hans-Jochen;Carare, Roxana O.;Schreiber, Stefanie
通讯作者：
Schreiber, Stefanie
影响因子：
29
作者：
Charidimou A;Martinez-Ramirez S;Reijmer YD;Oliveira-Filho J;Lauer A;Roongpiboonsopit D;Frosch M;Vashkevich A;Ayres A;Rosand J;Gurol ME;Greenberg SM;Viswanathan A
通讯作者：
Viswanathan A
DOI：
10.1161/hypertensionaha.112.195511
发表时间：
2012-07
期刊：
Hypertension (Dallas, Tex. : 1979)
影响因子：
--
作者：
Carnevale D;Mascio G;D'Andrea I;Fardella V;Bell RD;Branchi I;Pallante F;Zlokovic B;Yan SS;Lembo G
通讯作者：
Lembo G