Noninvasive measurements of regional cerebral perfusion in preterm and term neonates by magnetic resonance arterial spin labeling
Noninvasive measurements of regional cerebral perfusion in preterm and term neonates by magnetic resonance arterial spin labeling
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DOI：
10.1203/01.pdr.0000232785.00965.b3
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发表时间：
2006-09-01
影响因子：
3.6
通讯作者：
Sidaros, Karam
中科院分区：
文献类型：
--
作者：
Miranda, Maria J.;Olofsson, Kern;Sidaros, Karam
磁共振动脉自旋标记（ASL）在3特斯拉已被研究作为一种定量技术，用于测量新生儿局部脑灌注（RCP）。对49例健康新生儿（32例早产儿，17例足月儿）进行RCP值测定。两组均于月经后39-40周对未镇静的婴儿进行检查。由于运动，从23名早产儿和6名足月儿中获得了可靠的数据。在足月新生儿和足月新生儿中，基底神经节的灌注（早产儿和足月新生儿分别为39和30 mL/100 g/min）显著高于皮质灰质（19和16 mL/100 g/min）和白色物质（15和10 mL/100 g/min）（p < 0.0001）。早产儿组的灌注显著高于足月儿组（p = 0.01），表明RCP可能受发育和出生后年龄的影响。本研究首次证明，3 T下的无创ASL可用于测量健康未镇静早产儿和足月新生儿的RCP。因此，ASL是一种可行的工具，可以在高危新生儿中进行RCP系列研究。
Magnetic resonance arterial spin labeling (ASL) at 3 Tesla has been investigated as a quantitative technique for measuring regional cerebral perfusion (RCP) in newborn infants. RCP values were measured in 49 healthy neonates: 32 preterm infants born before 34 wk of gestation and 17 term-born neonates. Examinations were performed on unsedated infants at postmenstrual age of 39-40 wk in both groups. Due to motion, reliable data were obtained from 23 preterm, and 6 term infants. Perfusion in the basal ganglia (39 and 30 mL/100 g/min for preterm and term neonates, respectively) was significantly higher (p < 0.0001) than in cortical gray matter (19 and 16 mL/100 g/min) and white matter (15 and 10 mL/100 g/min), both in preterm neonates at term-equivalent age and in term neonates. Perfusion was significantly higher (p = 0.01) in the preterm group than in the term infants, indicating that RCP may be influenced by developmental and postnatal ages. This study demonstrates, for the first time, that noninvasive ASL at 3T may be used to measure RCP in healthy unsedated preterm and term neonates. ASL is, therefore, a viable tool that will allow serial studies of RCP in high-risk neonates.