Virus infection as a function of the host cell life cycle: replication of poliovirus RNA.
Virus infection as a function of the host cell life cycle: replication of poliovirus RNA.
复制标题
病毒感染作为宿主细胞生命周期的函数：脊髓灰质炎病毒 RNA 的复制。
DOI：
10.1099/0022-1317-16-1-61
复制
发表时间：
1972
期刊：
影响因子：
--
通讯作者：
P. Volpe
中科院分区：
文献类型：
--
作者：
T. Eremenko;A. Benedetto;P. Volpe
Summary
The rates of synthesis and final yields of poliovirus RNA varied considerably during the four main phases (G1, S, G2 and m) of the life cycle of synchronized HeLa cells. The rate of RNA synthesis late in virus growth (as measured by uridine incorporation 2 to 4 hr after infection) and the final yield of RNA rose sharply if growth was initiated towards the end of phase S; that is, RNA was synthesized most rapidly if cells were infected during the period of most rapid DNA synthesis. In contrast, the initial rate of RNA synthesis (incorporation 0 to 2 hr after infection) was greatest if growth was initiated at the end of phase G2, just before mitosis. This differential effect on growth kinetics suggests that the balance between the two stages of virus RNA synthesis (production of complementary minus strands and of progeny plus strands) is dependent on unknown cellular factors.
