A prospective study of anger and coronary heart disease - The normative aging study
A prospective study of anger and coronary heart disease - The normative aging study
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DOI：
10.1161/01.cir.94.9.2090
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发表时间：
1996-11-01
期刊：
影响因子：
37.8
通讯作者：
Weiss, ST
中科院分区：
文献类型：
--
作者：
Kawachi, I;Sparrow, D;Weiss, ST
背景 最近的实验室和流行病学研究表明，高度愤怒可能会增加冠心病 (CHD) 的风险。 方法和结果 我们在退伍军人管理局规范老龄化研究中前瞻性地研究了愤怒与 CHD 发病率的关系，该研究是一项正在进行的社区老年男性（平均年龄 61 岁）队列。 1986 年，共有 1305 名未诊断出先天性心脏病的男性完成了修订后的明尼苏达多相人格量表 (MMPI-2)。受试者根据他们对 MMPI-2 愤怒内容量表的反应进行分类，该量表衡量的是个人控制愤怒的困难程度。在平均7年的随访期间，发生了110例CHD事件，其中包括30例非致命性心肌梗塞（MI）、20例致命性CHD和60例心绞痛。与报告愤怒水平最低的男性相比，报告愤怒水平最高的男性中，总CHD（非致命性心肌梗死加致命性CHD）的多变量调整相对风险为3.15（95%置信区间[CI]：0.94至10.5），包括心绞痛在内的复合冠状动脉事件的多变量调整相对风险为2.66（95% CI：1.26至5.61）。愤怒程度与总体 CHD 风险之间存在剂量反应关系（趋势 P，0.008）。 结论 这些数据表明，高水平表达的愤怒可能是老年男性患 CHD 的危险因素。
Background Recent laboratory and epidemiological studies have suggested that high levels of anger may increase the risk of coronary heart disease (CHD).Methods and Results We examined prospectively the relationship of anger to CHD incidence in the Veterans Administration Normative Aging Study, an ongoing cohort of older (mean age, 61 years) community-dwelling men. A total of 1305 men who were free of diagnosed CHD completed the revised Minnesota Multiphasic Personality inventory (MMPI-2) in 1986. Subjects were categorized according to their responses to the MMPI-2 Anger Content Scale, which measures the degree to which individuals have problems controlling their anger. During an average of 7 years of follow-up, 110 cases of incident CHD occurred including 30 cases of nonfatal myocardial infarction hostility (MI), 20 cases of fatal CHD, and 60 cases of angina pectoris. Compared with men reporting the lowest levels of anger, the multivariate-adjusted relative risks among men reporting the highest levels of anger were 3.15 (95% confidence interval [CI]: 0.94 to 10.5) for total CHD (nonfatal MI plus fatal CHD) and 2.66 (95% CI: 1.26 to 5.61) for combined incident coronary events including angina pectoris. A dose-response relation was found between level of anger and overall CHD risk (P for trend, .008).Conclusions These data suggest that high levels of expressed anger may be a risk factor for CHD among older men.