Microvascular injury and hypoxic damage: emerging neuropathological signatures in COVID-19
Microvascular injury and hypoxic damage: emerging neuropathological signatures in COVID-19
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DOI：
10.1007/s00401-020-02190-2
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发表时间：
2020-07-08
影响因子：
12.7
通讯作者：
Brandner, Sebastian
中科院分区：
文献类型：
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作者：
Jaunmuktane, Zane;Mahadeva, Ula;Brandner, Sebastian
在COVID-19患者中，神经系统并发症被越来越多地认识到，但只有很少的神经病理学研究可用于记录微血栓和急性梗死[1]，无特异性病理[9]的缺氧改变或脑干[10]的血管周围淋巴细胞浸润。我们在此报告两名COVID-19患者的神经病理学结果，其中一名患者的发现与最近的病例报告中描述的结果惊人地相似，伴有新皮质梗死和小出血性和非出血性白质病变[8]，提示一种新的特征性改变模式，放射学上也观察到[3]。两例患者的临床资料见补充图1，神经病理学和影像学资料见图1、2和补充图2、3、4。
In patients with COVID-19, neurological complications are increasingly recognised, but only few neuropathological studies are available, documenting microthrombi and acute infarcts [1], hypoxic changes with no specific pathology [9] or perivascular lymphocytic infiltration in brainstem [10]. We report here neuropathology of two COVID-19 patients with findings in one strikingly similar to those described in a recent case report, with neocortical infarcts and small haemorrhagic and non-haemorrhagic white matter lesions [8], suggesting an emerging pattern of characteristic alterations, also observed radiologically [3]. Clinical data for both patients are provided in supplementary Fig. 1 and neuropathology and imaging in Figs. 1, 2 and supplementary Figs. 2, 3, 4.