Platelet Membrane Activation Markers Are Predictive for Increased Risk of Acute Ischemic Events After PTCA
Platelet Membrane Activation Markers Are Predictive for Increased Risk of Acute Ischemic Events After PTCA
复制标题
血小板膜激活标志物可预测 PTCA 后急性缺血事件风险增加
作者：
D. Tschoepe;H. P. Schultheif;P. Kolarov;B. Schwippert;K. Dannehl;Dipl Volksw;H. Nieuwenhuis;B. Kehrel;B. Strauer;F. Gries
背景：我们希望研究择期经皮腔内冠状动脉成形术（PTCA）后24小时内血小板活化是否与临床结果相关。方法和结果102例高级别冠状动脉狭窄择期行PTCA的患者，采用流式细胞术检测血小板表面膜上表达的CD62、CD63和血小板反应蛋白。手术后24小时内急性缺血事件的发生率与ptca前血小板激活状态有关。56名患者被归类为“非活化”，而46名患者显示活化血小板百分比增加。经二次冠状动脉造影证实，急性闭塞2例（1.96%），高度再狭窄4例（3.92%）。所有事件发生在被归类为“激活”的患者中（46例中有6例，即13%）。这些患者均未接受p受体阻滞剂药物治疗，p受体阻滞剂与血小板膜激活标志物表达降低有关。在未激活的患者组中，未发现临床事件（0 / 56，或0%）。患病率差异有统计学意义（P=0.007）。结论血小板膜活化标志物的分析可能有助于预测血管成形术后急性缺血性事件的风险增加。
BackgroundWe wished to investigate whether platelet activation is related to the clinical outcome during the 24 hours immediately after elective percutaneous transluminal coronary angioplasty(PTCA). Methods and ResultsIn 102 patients with high-grade coronary stenosis admitted for elective PTCA, preprocedural platelet activation was characterized by flow cytometric measurement of the proteins CD62, CD63, and thrombospondin expressed on the platelet surface membrane. The prevalence of acute ischemic events during the 24 hours immediately after the procedure was then related to the pre-PTCA platelet activation status. Fifty-six patients were classified as “nonactivated,” whereas 46 patients showed an increased percentage of activated platelets. Two patients developed acute occlusion (1.96 %) and four patients high-grade restenosis (3.92%), as confirmed by second-look coronary angiography. All events occurred in patients classified as “activated” (six of 46, or 13%). None of these patients received P-blocker medication, which was associated with lower expression of platelet membrane activation markers. In the nonactivated patient group, no clinical events were found (0 of 56, or 0%). This difference in prevalenceD is significant (P=0.007). ConclusionsWe conclude that analysis of platelet membrane activation markers may help to predict an increased risk of acute ischemic events after angioplasty.
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直接检测人体活化血小板和血小板衍生微粒。
影响因子：
20.3
作者：
Abrams,CS;Ellison,N;Budzynski,AZ;Shattil,SJ
通讯作者：
Shattil,SJ
通过荧光激活流式细胞术测量血小板活化。
DOI：
--
发表时间：
1990
期刊：
Blood cells
影响因子：
--
作者：
Corash,L
通讯作者：
Corash,L
动脉血管成形术后再狭窄：对损伤的血液流变学反应。
DOI：
10.1016/0002-9149(87)90477-2
发表时间：
1987
期刊：
The American journal of cardiology
影响因子：
--
作者：
Chesebro,JH;Lam,JY;Badimon,L;Fuster,V
通讯作者：
Fuster,V
影响因子：
37.8
作者：
Detre,KM;HolmesJr,DR;Holubkov,R;Cowley,MJ;Bourassa,MG;Faxon,DP;Dorros,GR;Bentivoglio,LG;Kent,KM;Myler,RK
通讯作者：
Myler,RK