Expression pattern of Wnt inhibitor factor 1(Wif1) during the development in mouse CNS
Expression pattern of Wnt inhibitor factor 1(Wif1) during the development in mouse CNS
复制标题
Wnt抑制因子1(Wif1)在小鼠中枢神经系统发育过程中的表达模式
DOI：
10.1016/j.gep.2008.06.001
复制
发表时间：
2008-09-01
影响因子：
1.2
通讯作者：
Zhao, Chunjie
中科院分区：
文献类型：
--
作者：
Hu, Yu-An;Gu, Xiaochun;Zhao, Chunjie
Wnt inhibitor factor-1 (WIF-1) is an extracellular antagonist of Wnts secreted proteins. Here we describe the expression pattern of Wif1 throughout the development of the Mouse central nervous system (CNS). Wif1 mRNA can be detected as early as the developmental stage E11, and expression persists to adulthood. In embryonic stages, the level of Wif1 expression Was Very prominent in several areas including the cerebral Cortex, the diencephalon and the midbrain, with the strongest level in the hippocampal plate and the diencephalon. However, after birth, the expression level of Wif1 decreased in the cortex and diencephalon. By adulthood, Wif1 is mainly expressed in the medial habenular nucleus (MHb) in the epithalamus, the mitral layer cells in the olfactory bulb and a few nuclei in the hypothalamus. Our data shows that the expression of Wif1 was very strong during embryonic development of the CNS and suggests that Wif1 may play an essential role in the spatial and temporal regulation of Wnt signals. (C) 2008 Published by Elsevier B.V.
