MODERN METABOLISM AS A PALIMPSEST OF THE RNA WORLD
MODERN METABOLISM AS A PALIMPSEST OF THE RNA WORLD
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DOI：
10.1073/pnas.86.18.7054
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发表时间：
1989-09-01
影响因子：
11.1
通讯作者：
TAUER, A
中科院分区：
文献类型：
--
作者：
BENNER, SA;ELLINGTON, AD;TAUER, A
开发了一种方法，利用当代生物体中发现的代谢途径、遗传组织、化学结构和酶反应机制的数据来构建古代生物体模型。这种方法通过“突破性生物体”模型的部分重建来说明，“突破性生物体”是最后一个使用 RNA 作为唯一基因编码生物催化剂的生物体。正如这里重建的，这种生物体具有复杂的新陈代谢，包括脱氢、转甲基、碳-碳键形成反应和基于磷酸酯的能量代谢。此外，突破性的生物体可能使用DNA来存储遗传信息，生物合成卟啉，并使用萜烯作为其主要脂质成分。该模型与主要基于遗传数据的流行模型显着不同。
An approach is developed for constructing models of ancient organisms using data from metabolic pathways, genetic organization, chemical structure, and enzymatic reaction mechanisms found in contemporary organisms. This approach is illustrated by a partial reconstruction of a model for the "breakthrough organism," the last organism to use RNA as the sole genetically encoded biological catalyst. As reconstructed here, this organism had a complex metabolism that included dehydrogenations, transmethylations, carbon-carbon bond-forming reactions, and an energy metabolism based on phosphate esters. Furthermore, the breakthrough organism probably used DNA to store genetic information, biosynthesized porphyrins, and used terpenes as its major lipid component. This model differs significantly from prevailing models based primarily on genetic data.