Electrophysiological Correlates of Rodent Default-Mode Network Suppression Revealed by Large-Scale Local Field Potential Recordings.
Electrophysiological Correlates of Rodent Default-Mode Network Suppression Revealed by Large-Scale Local Field Potential Recordings.
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DOI：
10.1093/texcom/tgab034
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发表时间：
2021-01-01
影响因子：
--
通讯作者：
Ramanathan, Dhakshin S
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文献类型：
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作者：
Fakhraei, Leila;Francoeur, Miranda;Ramanathan, Dhakshin S
人类的默认模式网络 (DMN) 由一组大脑区域组成，通过功能磁共振成像 (fMRI) 测量，这些区域显示出彼此之间的内在相关性以及外部导向任务期间的抑制。静息态功能磁共振成像研究此前已在啮齿类动物的重叠大脑区域（A29C/后扣带皮层、顶叶皮层和内侧颞叶结构）中发现了类似的内在相关性模式。然而，由于在 MRI 机器中执行啮齿动物行为的挑战，目前尚不清楚啮齿动物 DMN 区域的活动在外部导向的视觉任务期间是否受到抑制。通过对大鼠进行分布式局部场电位测量，我们发现上述 DMN 大脑区域的活动在 α 和低 β 频率的外部导向视觉任务中显示出与任务相关的抑制。有趣的是，这种抑制（特别是在后扣带皮层）与任务表现的提高有关。使用人类类似任务的脑电图记录，我们发现后扣带皮层在 α/低 β 频率下的活动受到类似的抑制。因此，我们在啮齿动物和人类中鉴定出了 DMN 抑制的常见电生理标志物。这一观察结果为未来使用啮齿动物探索 DMN 功能的回路水平功能的研究铺平了道路。 意义：在这里，我们表明，大鼠的 α/β 频率振荡显示了 DMN 活动的关键特征，包括 DMN 大脑区域之间的内在相关性、任务相关的抑制以及对注意力/决策的干扰。我们在人类 DMN 活动的 α/低 β 频率下发现了类似的任务相关抑制。
The default-mode network (DMN) in humans consists of a set of brain regions that, as measured with functional magnetic resonance imaging (fMRI), show both intrinsic correlations with each other and suppression during externally oriented tasks. Resting-state fMRI studies have previously identified similar patterns of intrinsic correlations in overlapping brain regions in rodents (A29C/posterior cingulate cortex, parietal cortex, and medial temporal lobe structures). However, due to challenges with performing rodent behavior in an MRI machine, it is still unclear whether activity in rodent DMN regions are suppressed during externally oriented visual tasks. Using distributed local field potential measurements in rats, we have discovered that activity in DMN brain regions noted above show task-related suppression during an externally oriented visual task at alpha and low beta-frequencies. Interestingly, this suppression (particularly in posterior cingulate cortex) was linked with improved performance on the task. Using electroencephalography recordings from a similar task in humans, we identified a similar suppression of activity in posterior cingulate cortex at alpha/low beta-frequencies. Thus, we have identified a common electrophysiological marker of DMN suppression in both rodents and humans. This observation paves the way for future studies using rodents to probe circuit-level functioning of DMN function.SIGNIFICANCE: Here we show that alpha/beta frequency oscillations in rats show key features of DMN activity, including intrinsic correlations between DMN brain regions, task-related suppression, and interference with attention/decision-making. We found similar task-related suppression at alpha/low beta-frequencies of DMN activity in humans.