Associations between corpus callosum size and ADHD symptoms in older adults: The PATH through life study
Associations between corpus callosum size and ADHD symptoms in older adults: The PATH through life study
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DOI：
10.1016/j.pscychresns.2016.08.009
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发表时间：
2016-10-30
影响因子：
2.3
通讯作者：
Cherbuin, Nicolas
中科院分区：
文献类型：
--
作者：
Luders, Eileen;Kurth, Florian;Cherbuin, Nicolas
注意缺陷/多动障碍（ADHD）的神经影像学研究揭示了儿童和青少年胼胝体的偏差。然而，胼胝体形态与成年期注意力不集中或多动症状之间的联系，尤其是在以后的生活中，所知甚少。在这里，我们调查了280名60多岁和70多岁的成年人（150名男性，130名女性）的大型人群样本，研究ADHD症状是否与胼胝体厚度相关。此外，我们测试了显著的性别相互作用，随后进行了按性别分层的相关分析。在男性中，不同胼胝体区域（包括前三分之一、前体和后体中部、峡部和脾）的注意力不集中和多动症存在显著负相关。胼胝体较薄可能与纤维较少或纤维髓鞘形成较少有关。因此，观察到的负相关表明，维持运动控制和注意力所必需的半球间通信通道受损，这可能导致多动症、冲动和/或注意力不集中的症状。有趣的是，在雌性中，胼胝体厚度与吻侧身体内一个小区域的过度活跃正相关，表明ADHD症状的性别二态神经生物学。总之，目前的结果可能反映了胼胝体形态和ADHD症状在一生中的持久关系。2016爱思唯尔爱尔兰有限公司版权所有。
Neuroimaging studies of attention-deficit/hyperactivity disorder (ADHD) have revealed deviations of the corpus callosum in children and adolescents. However, little is known about the link between callosal morphology and symptoms of inattention or hyperactivity in adulthood, especially later in life. Here, we investigated in a large population-based sample of 280 adults (150 males, 130 females) in their late sixties and early seventies whether ADHD symptoms correlate with callosal thickness. In addition, we tested for significant sex interactions, which were followed by correlation analyses stratified by sex. Within males, there were significant negative correlations with respect to inattention and hyperactivity in various callosal regions, including the anterior third, anterior and posterior midbody, isthmus, and splenium. A thinner corpus callosum may be associated with fewer fibers or less myelination of fibers. Thus, the observed negative correlations suggest impaired inter-hemispheric communication channels necessary to sustain motor control and attention, which may contribute to symptoms of hyperactivity, impulsivity and/or inattention. Interestingly, within females, callosal thickness was positively related to hyperactivity in a small area within the rostral body, suggesting a sexually dimorphic neurobiology of ADHD symptoms. Altogether, the present results may reflect a lasting relationship between callosal morphology and ADHD symptoms throughout life. (C) 2016 Elsevier Ireland Ltd. All rights reserved.