Basal forebrain lesions produce a dissociation of trial-dependent and trial-independent memory performance
Basal forebrain lesions produce a dissociation of trial-dependent and trial-independent memory performance
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基底前脑损伤导致试验依赖性和试验独立性记忆表现的分离
DOI：
10.1016/0006-8993(85)91008-x
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发表时间：
1985
期刊：
影响因子：
2.9
通讯作者：
J. Coyle
中科院分区：
文献类型：
--
作者：
B. Knowlton;G. Wenk;D. Olton;J. Coyle
用两种任务评估大鼠基底前脑(BF)损毁的行为效应。BF病变包括基底大细胞核(NBM)和内侧隔区(MSA)。第一个任务是石头迷宫，它有14个连续的选择点，是一个复杂的、独立于试验的记忆任务。在这项任务中，BF病变不会影响选择的准确性。第二个任务是在放射状手臂迷宫中进行Win-Shift空间辨别，这需要依赖于试验的记忆。在这项任务中，BF病变导致选择准确率显著下降。这些结果表明，BF病变损害了试验依赖(工作)记忆，但不损害试验非试验依赖的参考记忆，并且任务难度并不是BF病变是否产生行为障碍的唯一因素。
The behavioral effects of lesions in the basal forebrain (BF) of rats were evaluated using two tasks. The BF lesions included both the nucleus basalis magnocellularis (NBM) and the medial septal area (MSA). The first task was a Stone maze, which has 14 consecutive choice points and is a task of complex, trial-independent memory. BF lesions did not impair choice accuracy in this task. The second task was a win-shift spatial discrimination in a radial arm maze, which requires trial-dependent memory. BF lesions produced a significant decrease in choice accuracy in this task. These results demonstrate that BF lesions impair trial-dependent (working) memory but not trial-independent reference memory, and that task difficulty is not the sole factor determining whether BF lesions produce behavioral impairments.