A Case-Cohort Study to Investigate the Excess of Liver Cancer Observed in Workers in Poultry Slaughtering & Processing Plants.
A Case-Cohort Study to Investigate the Excess of Liver Cancer Observed in Workers in Poultry Slaughtering & Processing Plants.
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调查家禽屠宰工人肝癌患病率的病例队列研究
DOI：
10.1080/01635581.2019.1597901
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Johnson,EricS
中科院分区：
文献类型：
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作者：
Faramawi,MohammedF;Johnson,EricS
这是一项病例队列研究，旨在检验在家禽工厂工人中观察到的肝癌死亡过多是否可以用工厂内的致癌病毒和化学致癌物质暴露来解释。进行了详细的电话调查问卷，并通过逻辑回归分析了答复。家禽厂及相关行业中高暴露致癌病毒或化学致癌物的几项指标的比值比有所升高，但不具有统计显着性，但在厨房、饮食场所等直接接触肉血的比值比除外。既定的风险因素被复制，并发现了新的风险因素。该研究无法明确评估家禽厂中致癌病毒或化学致癌物暴露造成的风险，主要是因为观察到的风险升高并未达到统计显着性。这同样适用于一些非职业因素。确定的值得注意的风险因素包括吃卷心菜、贻贝、血肠、蛋白酥皮、踢足球的风险增加，以及经常摄入软饮料、明胶膳食、维生素、经常使用微波炉做饭、儿童疾病史和非特异性症状的风险降低。这些发现的意义尚不清楚，需要在具有足够统计能力的研究中进行重复。
This is a case-cohort study to examine whether the excess of liver cancer deaths observed in workers in poultry plants could be explained by oncogenic viruses and chemical carcinogenic exposures within the plants. A detailed telephone questionnaire was administered, and responses were analyzed by logistic regression. Odds ratios for several indicators of high exposure to oncogenic viruses or chemical carcinogens in poultry plants and related industries were elevated, but not statistically significant, except the odds ratio for direct contact with the blood of meat in kitchens, eating places, etc. Established risk factors were replicated, and new ones identified.The study was unable to unequivocally assess risks due to oncogenic viruses or chemical carcinogenic exposures in poultry plants, mainly because observed elevated risks did not achieve statistical significance. The same also applies to some non-occupational factors. Noteworthy risk factors identified include theincreasedrisks for eating cabbage, mussels, blood sausage, meringue, playing football, anddecreasedrisks for history of frequent intake of soft drinks, gelatin-based meals, vitamins, frequent use of microwave oven to cook, and history of childhood diseases, and nonspecific symptoms. The significance of these findings is unknown, and they will need to be replicated in studies with adequate statistical power.