Caffeine protects against increased risk-taking propensity during severe sleep deprivation
Caffeine protects against increased risk-taking propensity during severe sleep deprivation
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DOI：
10.1111/j.1365-2869.2010.00893.x
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发表时间：
2011-09-01
影响因子：
4.4
通讯作者：
Balkin, Thomas J.
中科院分区：
文献类型：
--
作者：
Killgore, William D. S.;Kamimori, Gary H.;Balkin, Thomas J.
以前的研究表明，睡眠不足与大脑区域内对判断和冲动控制很重要的代谢活动下降有关，但以前的研究报告了关于睡眠不足和咖啡因对冒险行为影响的不一致结果。在这项研究中，25名健康成年人（21名男性，4名女性）定期完成球囊模拟风险任务（BART）和风险评估（EVAR）量表，以检查75小时连续睡眠剥夺期间的行为和自我报告的冒险倾向。参与者在睡眠剥夺的3个晚上中的每一个晚上每两小时接受四次200 mg咖啡因（n = 12）或不可区分的安慰剂（n = 13）口香糖的双盲给药。在清醒51小时时测量时，药物组或睡眠剥夺对BART或EVAR无明显影响。然而，到75小时，安慰剂组在成本效益比和BART爆炸气球总数上的冒险行为显着增加，而咖啡因组保持在基线水平。在腹主动脉瘤腔内修复术中，在3天睡眠剥夺期间接受咖啡因的受试者中，自我报告的冒险倾向的几个因素（包括总风险、冲动性和风险/刺激寻求）降低，但安慰剂组保持在基线水平。这些结果表明，3个晚上的睡眠剥夺导致了行为冒险的显着增加，但没有自我报告的风险倾向的感知。隔夜咖啡因可以防止这种危险行为的增加。
Previous research suggests that sleep deprivation is associated with declines in metabolic activity within brain regions important for judgement and impulse control, yet previous studies have reported inconsistent findings regarding the effects of sleep loss and caffeine on risk-taking. In this study, 25 healthy adults (21 men, four women) completed the Balloon Analog Risk Task (BART) and Evaluation of Risks (EVAR) scale at regular intervals to examine behavioral and self-reported risk-taking propensity during 75 h of continuous sleep deprivation. Participants received either four double-blind administrations of 200 mg caffeine (n = 12) or indistinguishable placebo (n = 13) gum bi-hourly during each of the 3 nights of sleep deprivation. No significant effects of drug group or sleep deprivation were evident on the BART or EVAR when measured at 51 h of wakefulness. However, by 75 h, the placebo group showed a significant increase in risk-taking behavior on the cost-benefit ratio and total number of exploded balloons on the BART, whereas the caffeine group remained at baseline levels. On the EVAR, several factors of self-reported risk-taking propensity, including total risk, impulsivity and risk / thrill seeking, were reduced among subjects receiving caffeine across the 3 days of sleep deprivation, but remained at baseline levels for the placebo group. These results suggest that 3 nights of total sleep deprivation led to a significant increase in behavioral risk-taking but not self-reported perception of risk-propensity. Overnight caffeine prevented this increase in risky behavior.