Hepatitis E Virus Seroprevalence and Correlates of Anti-HEV IgG Antibodies in the Rakai District, Uganda
Hepatitis E Virus Seroprevalence and Correlates of Anti-HEV IgG Antibodies in the Rakai District, Uganda
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DOI：
10.1093/infdis/jix610
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发表时间：
2018-03-01
影响因子：
6.4
通讯作者：
Stabinski, Lara
中科院分区：
文献类型：
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作者：
Boon, Denali;Redd, Andrew D.;Stabinski, Lara
一项横断面研究对乌干达拉凯地区500名感染人类免疫缺陷病毒(HIV)的成年人和500名未感染HIV的人进行了年龄、性别和社区匹配，以评估抗戊型肝炎病毒(HEV)抗体的血清阳性率。HEV血清阳性率为47%，1名HIV感染者活跃地感染了3型病毒。经改良泊松回归分析，男性(患病率[PR]=1.247；95%可信区间[CI]1.071~1.450)和慢性乙肝病毒感染(PR=1.377；95%CI，1.090~1.738)与戊型肝炎病毒血清阳性率有关。HIV感染状况(PR=0.973；95%CI，0.852-1.111)与HEV血清阳性率无关。这些数据表明，乌干达农村地区先前接触HEV的负担很大。
A cross-sectional study was conducted of 500 human immunodeficiency virus (HIV)-infected adults frequency matched on age, sex, and community to 500 HIV-uninfected individuals in the Rakai District, Uganda to evaluate seroprevalence of anti-hepatitis E virus (HEV) IgG antibodies. HEV seroprevalence was 47%, and 1 HIV-infected individual was actively infected with a genotype 3 virus. Using modified Poisson regression, male sex (prevalence ratios [PR] = 1.247; 95% confidence interval [CI], 1.071-1.450) and chronic hepatitis B virus infection (PR = 1.377; 95% CI, 1.090-1.738) were associated with HEV seroprevalence. HIV infection status (PR = 0.973; 95% CI, 0.852-1.111) was not associated with HEV seroprevalence. These data suggest there is a large burden of prior exposure to HEV in rural Uganda.