Electromagnetic Field Treatment Protects Against and Reverses Cognitive Impairment in Alzheimer's Disease Mice
Electromagnetic Field Treatment Protects Against and Reverses Cognitive Impairment in Alzheimer's Disease Mice
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DOI：
10.3233/jad-2010-1228
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发表时间：
2010-01-01
影响因子：
4
通讯作者：
Cao, Chuanhai
中科院分区：
文献类型：
--
作者：
Arendash, Gary W.;Sanchez-Ramos, Juan;Cao, Chuanhai
尽管有许多研究，但没有明确的证据表明高频电磁场（EMF）暴露对人体健康构成风险。相反，这份报告提出了第一个证据，表明长期接触电磁场直接与手机使用（918 MHz; 0.25 W/kg）提供认知益处。电磁场暴露的认知保护和认知增强效应被发现用于正常小鼠和注定发展阿尔茨海默氏症样认知障碍的转基因小鼠。本研究中使用的认知干扰任务是从人类认知干扰任务设计的，并且与人类认知干扰任务类似。在阿尔茨海默氏病小鼠中，长期暴露于电磁场通过A β抗聚集作用减少了大脑淀粉样蛋白（A β）沉积，并在暴露期间增加了大脑温度。提出了几种相互关联的EMF作用机制，包括增加阿尔茨海默病小鼠大脑中A β的清除率，增加神经元活动和增加脑血流量。虽然在将这些小鼠研究外推到人类时应谨慎，但我们得出结论，EMF暴露可能代表了一种非侵入性，非药物治疗阿尔茨海默病和一种有效的记忆增强方法。
Despite numerous studies, there is no definitive evidence that high-frequency electromagnetic field (EMF) exposure is a risk to human health. To the contrary, this report presents the first evidence that long-term EMF exposure directly associated with cell phone use (918 MHz; 0.25 W/kg) provides cognitive benefits. Both cognitive-protective and cognitive-enhancing effects of EMF exposure were discovered for both normal mice and transgenic mice destined to develop Alzheimer's-like cognitive impairment. The cognitive interference task utilized in this study was designed from, and measure-for-measure analogous to, a human cognitive interference task. In Alzheimer's disease mice, long-term EMF exposure reduced brain amyloid-beta (A beta) deposition through A beta anti-aggregation actions and increased brain temperature during exposure periods. Several inter-related mechanisms of EMF action are proposed, including increased A beta clearance from the brains of Alzheimer's disease mice, increased neuronal activity, and increased cerebral blood flow. Although caution should be taken in extrapolating these mouse studies to humans, we conclude that EMF exposure may represent a non-invasive, non-pharmacologic therapeutic against Alzheimer's disease and an effective memory-enhancing approach in general.