Reverse Cochlear Propagation in the Intact Cochlea of the Gerbil: Evidence for Slow Traveling Waves
Reverse Cochlear Propagation in the Intact Cochlea of the Gerbil: Evidence for Slow Traveling Waves
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DOI：
10.1152/jn.00899.2009
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发表时间：
2010-03-01
影响因子：
2.5
通讯作者：
van der Heijden, Marcel
中科院分区：
文献类型：
--
作者：
Meenderink, Sebastiaan W. F.;van der Heijden, Marcel
Meenderink SWF，van der Heijden M.在沙土鼠完整耳蜗中的反向耳蜗波传播：慢行波的证据。神经生理学杂志103：1448-1455,2010。2010年1月20日首次出版；DOI：10.1152/jn.00899.2009。内耳可以发出声音，但这些耳声发射如何通过耳蜗反向传播目前还存在争议。有两种截然相反的观点：耳蜗液中的快速压力波和涉及基底膜的缓慢行波。解决这个问题需要测量从耳蜗源到耳道的排放物的传播时间。这是有问题的，因为产生辐射的准确位置尚不清楚，而且耳蜗易受侵入性测量的影响。我们采用了一种优化的多音调刺激来测量反向旅行时间。通过利用耳蜗的色散特性，并将耳道中的声学测量与耳蜗微音器电位的记录相结合，我们能够确定耳蜗内发射产生和它们在耳道中记录之间的群延迟。在补偿了中耳延迟后，这些延迟仍然很明显。这一结果与排放的反向传播完全是通过直接压力波的假设相矛盾。
Meenderink SWF, van der Heijden M. Reverse cochlear propagation in the intact cochlea of the gerbil: evidence for slow traveling waves. J Neurophysiol 103: 1448-1455, 2010. First published January 20, 2010; doi: 10.1152/jn.00899.2009. The inner ear can produce sounds, but how these otoacoustic emissions back-propagate through the cochlea is currently debated. Two opposing views exist: fast pressure waves in the cochlear fluids and slow traveling waves involving the basilar membrane. Resolving this issue requires measuring the travel times of emissions from their cochlear origin to the ear canal. This is problematic because the exact intracochlear location of emission generation is unknown and because the cochlea is vulnerable to invasive measurements. We employed a multi-tone stimulus optimized to measure reverse travel times. By exploiting the dispersive nature of the cochlea and by combining acoustic measurements in the ear canal with recordings of the cochlear-microphonic potential, we were able to determine the group delay between intracochlear emission-generation and their recording in the ear canal. These delays remained significant after compensating for middle-ear delay. The results contradict the hypothesis that the reverse propagation of emissions is exclusively by direct pressure waves.