Platelet function monitoring in patients with coronary artery disease
Platelet function monitoring in patients with coronary artery disease
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DOI：
10.1016/j.jacc.2007.07.051
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发表时间：
2007-11-06
影响因子：
24
通讯作者：
Michelson, Alan D.
中科院分区：
文献类型：
--
作者：
Gurbel, Paul A.;Becker, Richard C.;Michelson, Alan D.
近年来，针对患者对抗血小板治疗（特别是阿司匹林和氯吡格雷）的反应性的研究有所增加。然而，体内血小板功能和不良临床事件与离体血小板功能试验结果的关系在很大程度上仍然未知。本文介绍了目前在各种临床和研究情况下测量血小板功能的方法及其优缺点，回顾了抗血小板反应变异性和抵抗性的证据，讨论了监测血小板功能的潜在陷阱，并展示了支持血小板功能检测的积极临床和治疗意义的新数据。
Studies focused on patient responsiveness to antiplatelet therapies, particularly aspirin and clopidogrel, have increased in recent years. However, the relations of in vivo platelet function and adverse clinical events to results of ex vivo platelet function tests remain largely unknown. This article describes current methods of measuring platelet function in various clinical and research situations and their advantages and disadvantages, reviews evidence for antiplatelet response variability and resistance, discusses the potential pitfalls of monitoring platelet function, and demonstrates emerging data supporting the positive clinical and treatment implications of platelet function testing.