Salivary human immunodeficiency virus (HIV)-1-specific immunoglobulin A in HIV-1-exposed infants in Kenya
Salivary human immunodeficiency virus (HIV)-1-specific immunoglobulin A in HIV-1-exposed infants in Kenya
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DOI：
10.1111/j.1365-2249.2008.03664.x
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发表时间：
2008-07-01
影响因子：
4.6
通讯作者：
John-Stewart, G.
中科院分区：
文献类型：
--
作者：
Farquhar, C.;VanCott, T.;John-Stewart, G.
体液免疫，特别是针对人类免疫缺陷病毒(HIV)-1的免疫球蛋白A (IgA)，可能有助于防止粘膜表面的HIV-1获得。HIV-1特异性IgA已在HIV-1暴露的未感染HIV-1的商业性工作者的生殖道分泌物中检测到，并且可能在分娩和哺乳期间口服暴露于HIV-1的婴儿的腮腺唾液中产生。为了探索这一假设，我们收集了145名婴儿的唾液
Humoral immunity, and specifically immunoglobulin A (IgA) that is directed against human immunodeficiency virus (HIV)-1, may contribute to protection against HIV-1 acquisition at mucosal surfaces. HIV-1-specific IgA has been detected in genital tract secretions of HIV-1-uninfected commercial sex workers with HIV-1 exposure, and may be produced in parotid saliva by infants exposed orally to HIV-1 during delivery and breastfeeding. To explore this hypothesis, we collected saliva from 145 infants aged