The aging stress response.
The aging stress response.
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DOI：
10.1016/j.molcel.2010.10.002
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发表时间：
2010-10-22
期刊：
影响因子：
16
通讯作者：
Yankner BA
中科院分区：
文献类型：
--
作者：
Haigis MC;Yankner BA
衰老是损伤与修复平衡的结果。衰老的速度和年龄相关病理的出现受到应激反应和逐渐下降的修复途径的调节，包括蛋白质平衡和DNA损伤修复网络以及线粒体呼吸代谢。高度保守的胰岛素/IGF-1、TOR和sirtuin信号通路反过来控制这些关键的细胞反应。这些信号通路的协调作用维持细胞和生物体在面对外部扰动时的稳态，如营养物质有效性、温度和氧气水平的变化，以及内部扰动，如蛋白质错误折叠和DNA损伤。模式生物的研究表明，信号传导的变化可以增强这些关键的应激反应系统，延长寿命并减少与年龄相关的病理。因此，应激反应信号的系统生物学为理解和治疗与年龄有关的疾病提供了新的途径。
Aging is the outcome of a balance between damage and repair. The rate of aging and the appearance of age-related pathology are modulated by stress response and repair pathways that gradually decline, including the proteostasis and DNA damage repair networks and mitochondrial respiratory metabolism. Highly conserved insulin/IGF-1, TOR, and sirtuin signaling pathways in turn, control these critical cellular responses. The coordinated action of these signaling pathways maintains cellular and organismal homeostasis in the face of external perturbations, such as changes in nutrient availability, temperature and oxygen level, as well as internal perturbations, such as protein misfolding and DNA damage. Studies in model organisms suggest that changes in signaling can augment these critical stress response systems, increasing lifespan and reducing age-related pathology. The systems biology of stress response signaling thus provides a new approach to the understanding and potential treatment of age-related diseases.
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影响因子：
4.5
作者：
Fabrizio P;Hoon S;Shamalnasab M;Galbani A;Wei M;Giaever G;Nislow C;Longo VD
通讯作者：
Longo VD
生长激素受体的破坏可防止卡路里的限制改善胰岛素作用和寿命。
影响因子：
3.7
作者：
Bonkowski MS;Dominici FP;Arum O;Rocha JS;Al Regaiey KA;Westbrook R;Spong A;Panici J;Masternak MM;Kopchick JJ;Bartke A
通讯作者：
Bartke A
影响因子：
9.8
作者：
David DC;Ollikainen N;Trinidad JC;Cary MP;Burlingame AL;Kenyon C
通讯作者：
Kenyon C
影响因子：
64.8
作者：
通讯作者：
--
影响因子：
64.8
作者：
Cunningham, John T.;Rodgers, Joseph T.;Puigserver, Pere
通讯作者：
Puigserver, Pere