Low levels of 17-β-oestradiol, oestrone and testosterone correlate with severe evaporative dysfunctional tear syndrome in postmenopausal women: a case-control study
Low levels of 17-β-oestradiol, oestrone and testosterone correlate with severe evaporative dysfunctional tear syndrome in postmenopausal women: a case-control study
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DOI：
10.1136/bjophthalmol-2012-302705
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发表时间：
2014-03-01
影响因子：
4.1
通讯作者：
Avitabile, Teresio
中科院分区：
文献类型：
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作者：
Gagliano, Caterina;Caruso, Salvatore;Avitabile, Teresio
目的探讨重度蒸发性干眼综合征（DES）患者泪液渗透压、泪膜破裂时间（TF-BUT）、泪液分泌试验（Schirmer test）与血清性激素的关系，探讨17 β-雌二醇（E2）、雌酮（E3）和总睾酮（TT）缺乏在DES发病中的作用。22例重度蒸发性DES患者（A组）和22例无DES患者（B组）。进行的检查包括实验室血液分析：空腹血浆特征（17-β-雌二醇、雌酮和TT）、血糖水平和血脂特征。进行详细的眼部检查，包括角膜和结膜染色、泪液渗透压测量、泪液体积和TF-BUT。结果A组Schirmer试验和TF-BUT值明显低于B组（P
Aims To evaluate the role of 17-beta-oestradiol, oestrone and total testosterone (TT) deficiency in the pathogenesis of severe evaporative dry eye syndrome (DES), investigating the relationship between tear osmolarity, tear film break-up time (TF-BUT), Schirmer test and serum sex hormones in postmenopausal women.Methods 44 postmenopausal women were recruited for a case-control study: 22 women with severe evaporative DES (Group A) and 22 without DES (Group B). The tests performed included laboratory blood analysis: fasting plasma profile (17-beta-oestradiol, oestrone and TT), glucose level and lipid profile. Detailed eye examinations, including corneal and conjunctival staining, tear osmolarity measurement, tear volume and TF-BUT, were performed. The Ocular Surface Disease Index Questionnaire was also administered.Results Values of Schirmer test and TF-BUT in Group A were significantly lower in comparison with Group B (p