Bile acids: Natural ligands for an orphan nuclear receptor
Bile acids: Natural ligands for an orphan nuclear receptor
复制标题
DOI：
10.1126/science.284.5418.1365
复制
发表时间：
1999-05-21
期刊：
影响因子：
56.9
通讯作者：
Lehmann, JM
中科院分区：
文献类型：
--
作者：
Parks, DJ;Blanchard, SG;Lehmann, JM
胆汁酸通过人们知之甚少的分子机制来调节控制胆固醇稳态的基因转录。生理浓度的游离和结合的鹅去氧胆酸、石胆酸和脱氧胆酸激活法尼醇X受体（FXR；NR1H4），一种孤儿核受体。作为配体，这些胆汁酸及其缀合物调节 FXR 与源自类固醇受体辅激活剂 1 的肽的相互作用。这些结果为可能调节胆固醇稳态的核胆汁酸信号传导途径提供了证据。
Bile acids regulate the transcription of genes that control cholesterol homeostasis through molecular mechanisms that are poorly understood. Physiological concentrations of free and conjugated chenodeoxycholic acid, Lithocholic acid, and deoxycholic acid activated the farnesoid X receptor (FXR; NR1H4), an orphan nuclear receptor. As Ligands, these bile acids and their conjugates modulated interaction of FXR with a peptide derived from steroid receptor coactivator 1. These results provide evidence for a nuclear bile acid signaling pathway that may regulate cholesterol homeostasis.