The association between polymorphisms of genes related to inflammation and recurrent pregnancy loss
The association between polymorphisms of genes related to inflammation and recurrent pregnancy loss
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炎症相关基因多态性与复发性流产的关系
DOI：
10.1080/09513590.2017.1395837
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发表时间：
2018-01-01
影响因子：
2
通讯作者：
Du, Jing
中科院分区：
文献类型：
--
作者：
Gu, Yan;Wang, Jian Mei;Du, Jing
目的：复发性妊娠丢失（RPL）发生在1-2%的孕妇中，约50%的RPL病例原因不明。先前的研究表明，免疫反应基因的遗传变异可能导致妊娠期间维持妊娠的风险。本研究的目的是评估107例RPL病例和187名健康对照者的RPL与先前与炎症过程相关的基因之间的关系。方法：在这项工作中，利用直接测序和Sequenom MassARRAY系统检测了单核苷酸多态性。结果：FAU rs769440 G等位基因在RPL患者中的频率较高（p= 0.019）。结论：FAU rs769440基因多态性与RPL相关。
Aim: Recurrent pregnancy loss (RPL) occurs in 1-2% of pregnant women and about 50% of RPL cases are unexplained. Previous studies have shown that genetic variation in immune response genes can contribute to the risk in pregnancy maintenance during pregnancy. The aim of the present study was to evaluate the relationship between RPL and genes those have previously been associated with an inflammatory process on 107 RPL cases and 187 healthy controls.Methods: In this work, the single-nucleotide polymorphisms was examined by utilizing the direct sequencing and the Sequenom MassARRAY system.Results: The FAU rs769440G allele had higher frequencies in patients with RPL (p=.019). No association was observed between other polymorphisms and RPL.Conclusion: The results showed an association between FAU rs769440 polymorphism and RPL in Chinese Han population.