Risk factors for steroid-induced affective disorder in children with leukemia
Risk factors for steroid-induced affective disorder in children with leukemia
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DOI：
10.1002/pbc.28847
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发表时间：
2020-12-11
影响因子：
3.2
通讯作者：
Samsel, Chase
中科院分区：
文献类型：
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作者：
Muriel, Anna C.;Burgers, Darcy E.;Samsel, Chase
皮质类固醇是治疗儿童急性淋巴细胞性白血病(ALL)所必需的，并可引起显著的神经精神副作用。这篇回顾图表是对所有治疗过程中精神病学咨询和类固醇诱导的情感障碍(SIAD)相关特征的初步探索。在125例1-10岁的ALL患者中，56例(44.8%)接受了精神科咨询。在全部队列中，39人(31.2%)被诊断为SIAD。SIAD与家族精神病史显著相关，但与类固醇暴露、中枢神经系统辐射、社会人口学因素、发育迟缓、21三体或既往精神病史无关。收集家庭精神病史可能有助于识别SIAD风险增加的儿童。
Corticosteroids are essential to treating childhood acute lymphoblastic leukemia (ALL), and can cause significant neuropsychiatric side effects. This retrospective chart review is a preliminary exploration of characteristics associated with psychiatry consultation and steroid-induced affective disorder (SIAD) during ALL treatment. Of 125 ALL patients (ages 1-10 years), 56 (44.8%) received psychiatry consultation. Thirty-nine (31.2%) of the total cohort were diagnosed with SIAD. SIAD was significantly associated with family psychiatric history, but not with steroid exposure, CNS radiation, sociodemographic factors, developmental delay, Trisomy 21, or prior psychiatric history. Gathering family psychiatric history may help identify children at increased risk of SIAD.