Critical aspects of biointerface design and their impact on biosensor development
Critical aspects of biointerface design and their impact on biosensor development
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DOI：
10.1007/s00216-010-3637-4
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发表时间：
2010-03
影响因子：
4.3
通讯作者：
S. North;E. Lock;C. Taitt;S. Walton
中科院分区：
文献类型：
--
作者：
S. North;E. Lock;C. Taitt;S. Walton
生物识别元件在转导基底表面上的稳定集成是创建高性能传感器表面的最重要的一步。影响生物界面生物和非生物功能的关键因素是化学和物理的。了解生物分子和表面之间的相互作用及其复杂性对于传感应用的生物界面实施至关重要。在本概述中，我们重点介绍通常用于生物传感器开发的材料和方法。特别强调生物界面特性和功能的实验评估。提出了生物界面在生物传感中应用的有前景的研究方向。图纳米级粗糙度、表面元素组成和功能性生物固定之间的相关性。
The stable integration of a biological recognition element on a transducing substrate surface is the single most important step in the creation of a high-functioning sensor surface. The key factors affecting biotic and abiotic functionalities at the biointerface are both chemical and physical. Understanding the interactions between biomolecules and surfaces, and their emergent complexity, is critical for biointerface implementation for sensing applications. In this overview, we highlight materials and methods typically used for biosensor development. Particular emphasis has been given to the experimental evaluation of biointerfacial properties and functionality. Promising research directions for application of biointerfaces to biosensing are suggested.FigureCorrelation between nanoscale roughness, surface elemental composition, and functional bio-immobilization.