Age decreases nitric oxide synthase-containing nerve fibers in the rat penis
Age decreases nitric oxide synthase-containing nerve fibers in the rat penis
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DOI：
10.1016/s0022-5347(01)65147-4
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发表时间：
1997-03-01
影响因子：
6.6
通讯作者：
Lue, TF
中科院分区：
文献类型：
--
作者：
Carrier, S;Nagaraju, P;Lue, TF
目的：为探讨衰老对大鼠勃起功能的影响，材料与方法：1）阴茎海绵体及背神经内血管活性肠肽（VIP）和一氧化氮合酶（NOS）神经纤维的数量和分布;和2）阿扑吗啡的勃起反应（一种中枢多巴胺受体激动剂）、海绵体神经电刺激和脑内注射罂粟碱。老年大鼠含NOS神经纤维数量明显减少（24个月）比年轻的（2.5个月）和（8.5个月）-老化（63.3 ± 3.35 vs. 135.1 ± 10.88 [p ≤ 0.0002]和127.8 ± 11.65 [p ≤ 0.0002]）。阿扑吗啡诱导的勃起次数在老年大鼠中明显少于年轻大鼠（1.0 +/- 3.1 vs. 3.6 +/- 0.26; p < 0.002）。在电刺激下，海绵体内压力上升开始前的潜伏期随着年龄的增长而增加（2.3 ± 0.24秒）。对于年轻人，6.77 +/- 0.98秒。对于老年人，p小于或等于0.0001）。海绵体内注射罂粟碱后的最大海绵体内压随年龄的增长而下降。结论：勃起机制似乎保持完整，大鼠年龄，但对中枢和外周刺激的反应下降。含NOS神经纤维的减少可能解释了这些观察结果。
Purpose: To study the effect of aging on erectile function in a rat model.Materials and Methods: We investigated: 1) the number and distribution of nerve fibers within the corpus cavernosum and dorsal nerve containing vasoactive intestinal polypeptide (VIP) and nitric oxide synthase (NOS); and 2) the erectile response to apomorphine (a central dopamine receptor agonist), electrostimulation of the cavernous nerve, and intracorporeal papaverine injection.Results: The number of NOS-containing nerve fibers was significantly less in the old rats (24 months) than in the young (2.5 months) and intermediate (8.5 months)-aged (63.3 +/- 3.35 vs. 135.1 +/- 10.88 [p less than or equal to 0.0002] and 127.8 +/- 11.65 [p less than or equal to 0.0002]). The number of erections induced by apomorphine was significantly less in the old rats than in the young (1.0 +/- 3.1 vs. 3.6 +/- 0.26; p < 0.002). With electrostimulation, the latency period before the onset of the intracavernous pressure rise was noted to increase with age (2.3 +/- 0.24 sec. for the young vs. 6.77 +/- 0.98 sec. for the old, p less than or equal to 0.0001). The maximal intracavernous pressure after intracavernous papaverine injection decreased with age.Conclusion: The erectile mechanism appears to remain intact as rats age, but the response to central and peripheral stimulation decreases. The reduction in NOS-containing nerve fibers might account for these observations.