Functional Connectivity Bias of the Orbitofrontal Cortex in Drug-Free Patients with Major Depression
Functional Connectivity Bias of the Orbitofrontal Cortex in Drug-Free Patients with Major Depression
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DOI：
10.1016/j.biopsych.2009.08.022
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发表时间：
2010-01-15
影响因子：
10.6
通讯作者：
Meisenzahl, Eva
中科院分区：
文献类型：
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作者：
Frodl, Thomas;Bokde, Arun L. W.;Meisenzahl, Eva
工作背景：眶额皮层（OFC）在情绪处理回路中起着至关重要的作用，因此也应该包括在抑郁症的病理生理模型中。本研究的目的是比较重性抑郁症患者和健康对照者情绪处理过程中眶额皮质的功能连接性。方法：使用功能性磁共振成像对25名未经治疗的重性抑郁症患者和15名健康对照者进行了调查面部匹配任务。结果：背前扣带皮层、楔前叶和小脑活动与眶额皮层的连接性低于对照组。与此相反，OFC和右背外侧前额叶皮层（DLPFC），右下额叶盖，左运动区之间的功能连接增加患者与健康对照subjects.Conclusions：OFC起着关键作用，在抑郁症的病理生理。观察到的OFC连接的不平衡似乎代表了加工偏向的神经机制。从神经生物学的角度来看，楔前叶和扣带回的活动从眶额皮层的解耦可能与自我图式的调节问题，而增加连接的DLPFC的眶额皮层可能代表了一个更高的神经反应的负面刺激。
Background: The orbitofrontal cortex (OFC) plays a crucial role in emotion-processing circuits and should therefore also be included in models of the pathophysiology of major depression. The aim of this study was to compare the functional connectivity of the OFC during emotion processing in patients with major depression and healthy control subjects.Methods: Twenty-five untreated patients with major depression and 15 healthy control subjects were investigated using a functional magnetic resonance imaging face-matching task.Results: Dorsal anterior cingulate cortex, precuneus, and cerebellum activity showed less connectivity with the OFC in patients than in control subjects. In contrast, functional connectivity between the OFC and the right dorsolateral prefrontal cortex (DLPFC), right inferior frontal operculum, and left motor areas was increased in patients compared with healthy control subjects.Conclusions: The OFC plays a key role in the pathophysiology of major depression. The observed imbalance of OFC connectivity seems to represent a neural mechanism of the processing bias. From a neurobiological point of view, the uncoupling of precuneus and gyrus cinguli activity from the OFC might be associated with problems in the regulation of self-schemas, whereas the increased connectivity of the DLPFC to the OFC might represent a higher neural response to negative stimuli.