EFFECTS OF ADRENALINE AND NORADRENALINE ON GLUCOSE-INDUCED ELECTRICAL-ACTIVITY OF MOUSE PANCREATIC BETA-CELL
EFFECTS OF ADRENALINE AND NORADRENALINE ON GLUCOSE-INDUCED ELECTRICAL-ACTIVITY OF MOUSE PANCREATIC BETA-CELL
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DOI：
10.1113/expphysiol.1983.sp002716
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发表时间：
1983-01-01
影响因子：
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通讯作者：
ATWATER, I
中科院分区：
文献类型：
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作者：
DESA, SS;FERRER, R;ATWATER, I
在显微解剖的小鼠胰岛中研究了肾上腺素和去甲肾上腺素对膜电位和葡萄糖诱导的电活动的影响。在11·1 mM葡萄糖存在下，两种儿茶酚胺均诱导超极化并阻断电活动。酚妥拉明（而非普萘洛尔）可阻断这些作用，表明主要是α受体作用。奎宁，但不是四乙基铵离子，拮抗的抑制作用的儿茶酚胺。这些数据与α受体激活诱导细胞内Ca2+浓度瞬时增加进而导致K+渗透性增加的假设一致。
The effects of adrenaline and noradrenaline on membrane potential and glucose‐induced electrical activity were studied in micro‐dissected mouse Islets of Langerhans. Both catecholamines induced hyperpolarization and blocked electrical activity in the presence of 11·1 mM glucose. Phentolamine, but not propranalol, blocked these effects, indicating predominantly α receptor action. Quinine, but not tetraethylammonium ions, antagonized the inhibitory effects of the catecholamines. The data are consistent with the hypothesis that α receptor activation induces a transient increase in intracellular Ca2+concentration which in turn leads to an increase in K+permeability.