Biocompatible Photoluminescent Silk Fibers with Stability and Durability
Biocompatible Photoluminescent Silk Fibers with Stability and Durability
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具有稳定性和耐用性的生物相容性光致发光丝纤维
DOI：
10.1021/acsbiomaterials.9b00200
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发表时间：
2019
影响因子：
--
通讯作者：
Zhang Qi Qing
中科院分区：
文献类型：
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作者：
He Yuan;Zhang Li Mei;Chen Yong Mei;Sun Lei;Mei Chen;Wang Mei Xiang;Gao Yang;Yang Jian Hai;Zhang Qi Qing
探索具有生物相容性和稳定持久荧光性能的光致发光丝纤维是开发新型光致发光生物材料的需要。本文通过在蚕丝纤维上修饰有机荧光分子（5-氧代-3，5-二氢-2H-噻唑并[3，2-a]吡啶-7-羧酸，TPCA），沿着以季铵盐双十二烷基二甲基溴化铵（DDAB）为固色剂，制备了光致发光蚕丝纤维TPCA@SF。丝素纤维、TPCA和DDAB之间的氢键和静电缔合作用保证了改性的稳定性。在温和的条件下，在水中实现了简单和绿色的制造过程，而不使用任何有毒物质。TPCA@SF具有量子产率高、荧光耐水、抗光漂白、力学性能好、生物相容性好等特点。该策略具有巨大的潜力，探索各种生物相容性的光致发光物质的稳定性和耐久性。
Exploring photoluminescent silk fibers, possessing biocompatibility as well as stable and durable fluorescent properties, is a requirement for the development of novel photoluminescent biomaterials. Herein, we fabricate photoluminescent silk fibers, TPCA@SF, via modifying an organic fluorescent molecule (5-oxo-3,5-dihydro-2H-thiazolo [3,2-a] pyridine-7-carboxylic acid, TPCA) onto silk fibers, along with using quaternary ammonium salt didodecyldimethylammonium bromide (DDAB) as a color-fixing agent. The hydrogen bonds and electrostatic association among silk fibers, TPCA and DDAB, ensure the stable modification. The facile and green fabrication process is achieved in water under mild conditions without using any toxic substances. The TPCA@SF manifests the combining features of high quantum yield, fluorescence water-fastness, antiphotobleaching, good mechanical property, and biocompatibility. The strategy holds great potential for exploring various biocompatible photoluminescent substances with stability and durability.