Single-exposure optical focusing inside scattering media using binarized time-reversed adapted perturbation.
Single-exposure optical focusing inside scattering media using binarized time-reversed adapted perturbation.
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DOI：
10.1364/optica.2.000869
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发表时间：
2015-10
期刊：
影响因子：
10.4
通讯作者：
Wang LV
中科院分区：
文献类型：
--
作者：
Ma C;Zhou F;Liu Y;Wang LV
光散射通过防止聚焦抑制高分辨率光学成像、操纵和治疗深入生物组织。为了形成深焦，波前整形技术突破了光扩散的限制。对于体内应用，这样的聚焦必须提供高增益、高速和高焦峰背景比。然而，前面的技术都不能同时满足这些需求。在这里，我们克服了这一挑战，通过快速测量扰动光场在一个单一的相机曝光，然后自适应时间反转相位二值化的扰动。因此，相位共轭波前在一毫秒内合成，比数字实现的记录短两个数量级。我们演示了动态散射介质的实时聚焦，并将激光散斑对比度成像扩展到新的深度。前所未有的快速响应、高增益和高聚焦对比度的结合，使这项工作在体内深部组织光学成像、操作和治疗方面迈出了一大步。
Light scattering inhibits high-resolution optical imaging, manipulation and therapy deep inside biological tissue by preventing focusing. To form deep foci, wavefront shaping techniques that break the optical diffusion limit have been developed. For in vivo applications, such focusing must provide high gain, high speed, and a high focal peak-to-background ratio. However, none of the previous techniques meet these requirements simultaneously. Here, we overcome this challenge by rapidly measuring the perturbed optical field within a single camera exposure followed by adaptively time-reversing the phase-binarized perturbation. Consequently, a phase-conjugated wavefront is synthesized within a millisecond, two orders of magnitude shorter than the digitally achieved record. We demonstrated real-time focusing in dynamic scattering media, and extended laser speckle contrast imaging to new depths. The unprecedented combination of fast response, high gain, and high focusing contrast makes this work a major stride toward in vivo deep tissue optical imaging, manipulation, and therapy.