Wingless signaling initiates mitosis of primordial germ cells during development in Drosophila
Wingless signaling initiates mitosis of primordial germ cells during development in Drosophila
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DOI：
10.1016/j.mod.2008.01.004
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发表时间：
2008-05
影响因子：
2.6
通讯作者：
Takuya Sato;Sachie Ueda;Y. Niki
中科院分区：
文献类型：
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作者：
Takuya Sato;Sachie Ueda;Y. Niki
果蝇的生殖细胞来源于极细胞，极细胞形成于胚盘的后极并成为原始生殖细胞（PGCs）。为了阐明胚胎PGCs发育的信号转导途径，我们研究了各种生长因子对PGCs增殖的影响。上调和下调索马和PGCs中的Wingless（Wg）分别引起PGCs数量的增加和减少。Wg/β-catenin信号通路在两性胚胎期PGCs开始分裂的同时开始在PGCs中发生。此外，发现PGCs在开始分裂时产生wg mRNA。因此，Wg作为一种自分泌因子启动胚胎PGCs的有丝分裂。从胚胎末期开始，偏瘫对PGCs的生长有影响。结果表明，这些生长因子调节分裂的胚胎PGCs在特定阶段的方式。
The germline cells of Drosophila are derived from pole cells, which form at the posterior pole of the blastoderm and become primordial germ cells (PGCs). To elucidate the signal transduction pathways for the development of embryonic PGCs, we examined the effects of various growth factors on the proliferation of PGCs. Up- and down-regulation of Wingless (Wg) in both of soma and PGCs caused an increase and a decrease in the number of PGCs, respectively. The Wg/β-catenin signaling pathway began to occur in PGCs at the same time as the PGCs began to divide during the embryonic stage in both sexes. In addition, PGCs were found to produce wg mRNA as they begin to divide. Thus, Wg functions as an autocrine factor to initiate mitosis in embryonic PGCs. Decapentaplegic affected the growth of PGCs from the end of the embryonic stage. The results indicate that these growth factors regulate the division of embryonic PGCs in a stage-specific manner.