Role of obesity in GORD-related disorders
Role of obesity in GORD-related disorders
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DOI：
10.1136/gut.2007.127878
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发表时间：
2008-03-01
期刊：
影响因子：
24.5
通讯作者：
El-Serag, Hashem B.
中科院分区：
文献类型：
--
作者：
El-Serag, Hashem B.
肥胖满足与GORD及其并发症因果关系的几个标准，包括普遍一致的关联和一些剂量-反应关系。腹部肥胖似乎在很大程度上解释了这种关联，主要通过增加胃内压、胃食管梯度、TLOSR和食管酸暴露来实现。其他体液机制在巴雷特食管和食管腺癌中可能很重要，但这方面的研究还很少。维持正常体重可以降低发生GORD及其潜在并发症的可能性。
Obesity satisfies several criteria for a causal association with GORD and its complications including generally consistent association and some dose-response relationship. Abdominal obesity seems to explain a considerable part of this association operating mostly by increasing intragastric pressure, gastroesophageal gradient, TLOSR, and oesophageal acid exposure. Additional humoral mechanisms may be important in Barrett's oesophagus and oesophageal adenocarcinoma but this remains poorly examined. Maintaining normal weight may reduce the likelihood of developing GORD and its potential complications.