Integrin expression in oral hairy leukoplakia and normal tongue epithelium.
Integrin expression in oral hairy leukoplakia and normal tongue epithelium.
复制标题
口腔毛状白斑和正常舌上皮中的整合素表达。
DOI：
10.1111/j.1601-0825.2000.tb00119.x
复制
发表时间：
2000
期刊：
影响因子：
3.8
通讯作者：
Palefsky,JM
中科院分区：
文献类型：
--
作者：
Chainani-Wu,N;Lagenaur,LA;Peñaranda,ME;Palefsky,JM
OBJECTIVE: To describe the expression of integrins in the epithelium of oral hairy leukoplakia (HL) and compare to that of normal lateral tongue epithelium. MATERIALS AND METHODS: Immunohistochemistry to identify integrins (α2, a α5, α6, αv, β1) was performed, using a standard biotin‐streptavidin‐peroxidase technique on five clinically and histologically confirmed frozen biopsy specimens of HL and five normal lateral tongue control tissues.RESULTS: Expression of integrins α2, α3, α6, αv, β1 was seen both in HL epithelium and in normal control tissue.α5 expression was not seen in HL or in control tissue epithelium.α2 and α3 were expressed mainly in the basal and suprabasal layers; α6 expression was most intense on the basal surface of the basal cells, αv was expressed in the basal and suprabasal layers with more expression seen in the higher differentiated cell layers than the other integrins.β1 expression was seen in the basal and suprabasal layers only. No apparent difference between HL and normal oral mucosa was noted in the staining pattern of the various integrins.CONCLUSION: Integrins α2, α3, α6, αv, β1 are expressed in HL and the expression pattern is not different from that of normal oral mucosa.α5 is not expressed in HL or in normal oral epithelium.
