Investigating dopaminergic neurotransmission with 123I-FP-CIT SPECT: comparability of modern SPECT systems.
Investigating dopaminergic neurotransmission with 123I-FP-CIT SPECT: comparability of modern SPECT systems.
复制标题
使用 123I-FP-CIT SPECT 研究多巴胺能神经传递：现代 SPECT 系统的可比性。
作者：
P. Meyer;B. Sattler;T. Lincke;A. Seese;O. Sabri
未标记
随着（123）I标记的N-ω-氟丙基-2-β-甲氧羰基-3-β-（4-碘苯基）去甲托烷（FP-CIT）SPECT越来越多地进入常规患者护理，不同SPECT系统在受体结合定量方面的结果的可比性对于准确的临床决策和机构之间成像结果的转换（例如，作为多中心治疗试验的一部分）。
方法
在一系列使用体模（包含直径为2和2.8 cm的目标圆柱体）和（123）I-FP-CIT患者研究（n = 49）的研究中，我们比较了传统三探头SPECT系统和专用高分辨率脑SPECT系统恢复的目标与背景（T/BG）和（123）I-FP-CIT纹状体摄取比。使用单次注射方案（A组[n = 20]首先在三头SPECT系统上扫描，B组[n = 29]首先在专用脑SPECT系统上扫描），在两个SPECT系统上连续采集所有患者研究（<15分钟扫描间隙）。
结果
在体模研究中，两种系统恢复的T/BG比与真实的T/BG比密切相关（R（2）> 0.96），专用脑SPECT和三探头SPECT系统的线性回归斜率分别为0.86-1.17和0.41-0.52（较小的靶尺寸和较低的T/BG比较不陡峭）。尽管两种系统产生的结果明显不同，但它们显示出彼此之间的高度线性相关性（R（2）> 0.95，靶大小没有显著影响）。在（123）I-FP-CIT患者研究中，发现了类似的系统间线性相关性（纹状体、尾状核和壳核与枕叶参考区的摄取比率的R（2）[A/B]分别为0.79/0.80、0.52/0.68和0.83/0.85）。
结论
不同SPECT系统之间纹状体摄取比率的线性转换似乎对于配体如（123）I-FP-CIT是可实现的。需要评估本方法是否能够以足够的准确度达到临床目的，或者是否有必要进行方法学调整。必须确保适当的研究时间。
UNLABELLED
With (123)I-labeled N-omega-fluoropropyl-2-beta-carbomethoxy-3-beta-(4-iodophenyl)nortropane (FP-CIT) SPECT increasingly gaining access into routine patient care, the comparability of the results of different SPECT systems in the quantification of receptor binding is important for accurate clinical decision making and the translation of imaging results between institutions (e.g., as part of multicenter therapy trials).
METHODS
In a series of studies using phantoms (containing target cylinders of 2- and 2.8-cm diameter) and (123)I-FP-CIT patient studies (n = 49), we compared target-to-background (T/BG) and (123)I-FP-CIT striatal uptake ratios recovered by a conventional triple-head SPECT system and a dedicated high-resolution brain SPECT system. All patient studies were acquired on both SPECT systems successively (<15-min interscan gap) using a single-injection protocol (group A [n = 20] was first scanned on the triple-head SPECT system, and group B [n = 29] was first scanned on the dedicated brain SPECT system).
RESULTS
In phantom studies, the T/BG ratios recovered by both systems correlated strongly with the true T/BG ratios (R(2) > 0.96), with the linear regression slopes being 0.86-1.17 and 0.41-0.52 (less steep for smaller target size and lower T/BG ratios) for the dedicated brain SPECT and the triple-head SPECT system, respectively. Although both systems yielded markedly different results, they showed a high linear correlation with each other (R(2) > 0.95, no significant effect from target size). In (123)I-FP-CIT patient studies, a similar linear intersystem correlation was found (R(2) [A/B] = 0.79/0.80, 0.52/0.68, and 0.83/0.85 for the uptake ratios of the striatum, caudate, and putamen, respectively, to the occipital reference region).
CONCLUSION
A linear transformation of striatal uptake ratios between different SPECT systems appears to be achievable for ligands such as (123)I-FP-CIT. An evaluation is needed of whether the present method can do this with sufficient accuracy for clinical purposes or whether methodologic adaptations are necessary. Proper study timing has to be ensured.