Inflated wings, tissue autolysis and early death in tissue inhibitor of metalloproteinases mutants of Drosophila
Inflated wings, tissue autolysis and early death in tissue inhibitor of metalloproteinases mutants of Drosophila
复制标题
DOI：
10.1078/0171-9335-00072
复制
发表时间：
2000-07-01
影响因子：
6.6
通讯作者：
Buchner, E
中科院分区：
文献类型：
--
作者：
Godenschwege, TA;Pohar, N;Buchner, E
在脊椎动物中，组织金属蛋白酶抑制剂（TIMPs）在细胞外基质（ECM）稳态和生长控制中起着关键作用。删除最近克隆的果蝇Timp基因导致亚活表型。成年苍蝇表现出与整合素突变体相似的膨胀翅膀，患有肿胀的肠道和内部组织的逐渐溶解，并且过早死亡。我们的研究结果表明Timp基因产物控制着果蝇ECM功能的选择性方面，并表明它参与细胞粘附/细胞信号通路。因此，果蝇Timp突变体可能被证明是与ECM失调相关的各种病理状况的模型系统。
In vertebrates, tissue inhibitors of metalloproteinases (TIMPs) play key roles in extracellular matrix (ECM) homeostasis and growth control. Deletion of the recently cloned Timp gene of Drosophila results in a subviable phenotype. Adult flies display inflated wings similar to integrin mutants, suffer from a bloated gut and progressive dissolution of internal tissues, and die prematurely. Our results demonstrate that the Timp gene product controls selective aspects of ECM function in Drosophila, and suggest that it is involved in cell adhesion/cell signaling pathways. Hence, Drosophila Timp mutants may prove useful as a model system for a wide variety of pathological conditions related to ECM dysregulation.