Trabecular surface remodeling simulation for cancellous bone using microstructural voxel finite element models
Trabecular surface remodeling simulation for cancellous bone using microstructural voxel finite element models
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DOI：
10.1115/1.1392315
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发表时间：
2001-10-01
影响因子：
1.7
通讯作者：
Hollister, SJ
中科院分区：
文献类型：
--
作者：
Adachi, T;Tsubota, K;Hollister, SJ
提出了一种基于松质骨体素有限元模型的三维小梁表面重构计算模拟方法，并将其应用于实验数据。在仿真中，基于数字图像对小梁微观结构进行建模，通过对小梁表面进行体素元素的去除/添加，直接表达小梁水平表面运动引起的形态变化。在单轴压缩载荷下，单小梁水平的重塑模拟显示，即使小梁用离散体素元素建模，其形态也会发生平滑变化。此外，小梁轴向加载方向旋转，随着刚度的增加，模拟了对外加载荷的功能适应。在小梁结构水平的重塑模拟中，使用微计算机断层扫描（mu CT）获得的数字图像对松质骨立方体进行建模，并进行单轴压缩。结果，骨小梁向加载方向重新定向后，骨小梁抗载荷表观刚度增加。此外，小梁结构指标的变化与先前发表的实验观察结果定性一致。通过这些研究表明，新提出的体素模拟技术可以模拟小梁表面重塑，并将该技术获得的结果与体内实验数据进行比较，以研究适应性骨重塑现象。
A computational simulation method for three-dimensional trabecular surface remodeling was proposed, using voxel finite element models of cancellous bone, and was applied to the experimental data. In the simulation, the trabecular microstructure was modeled based on digital images, and its morphological changes due to surface movement at the trabecular level were directly expressed by removing/adding the voxel elements from/to the trabecular surface. A remodeling simulation at the single trabecular level under uniaxial compressive loading demonstrated smooth morphological changes even though the trabeculae were modeled with discrete voxel elements. Moreover the trabecular axis rotated toward the loading direction with increasing stiffiness, simulating functional adaptation to the applied load. In the remodeling simulation at the trabecular structural level, a cancellous bone cube was modeled using a digital image obtained by microcomputed tomography (mu CT), and was uniaxially compressed. As a result, the apparent stiffness against the applied load increased by remodeling, in which the trabeculae reoriented to the loading direction. In addition, changes in the structural indices of the trabecular architecture coincided qualitatively with previously published experimental observations. Through these studies, it was demonstrated that the newly proposed voxel simulation technique enables us to simulate the trabecular surface remodeling and to compare the results obtained using this technique with the in vivo experimental data in the investigation of the adaptive bone remodeling phenomenon.