Fine structure of host-graft relationships between transplanted chromaffin cells and CNS.
Fine structure of host-graft relationships between transplanted chromaffin cells and CNS.
复制标题
移植的嗜铬细胞与中枢神经系统之间宿主-移植物关系的精细结构。
DOI：
10.1096/fasebj.13.9002.s277
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
Pappas,GD
中科院分区：
文献类型：
--
作者：
Pappas,GD
Our laboratory studies have shown that transplantation of adrenal medullary tissue or isolated chromaffin cells into central nervous system (CNS) pain modulatory regions (i.e., periaqueductal gray and subarachnoid lumbar spinal cord) can reduce pain sensitivity of rats in both acute and chronic pain. The analgesia produced by these transplants is thought to result from release of both opiate peptides and catecholamines. Morphologically, these animal studies also suggest that there is no development of tolerance over long periods of time, and the transplanted chromaffin cells appear to be robust and well integrated with the host tissue. In our initial clinical studies, where allografts of adrenal medullary tissue were transplanted intrathecally to relieve intractable cancer pain, patients obtained significant and long‐lasting pain relief. Increased cerebrospinal fluid (CSF) levels of metenkephalin were correlated with the decreased pain scores. Histology of autopsy tissue obtained from two patients with 1 year transplants revealed viable transplanted chromaffin cells. Because of the limited availability of human adrenal glands, sources of xenogeneic chromaffin cells will need to be identified if effective transplantation therapy for chronic pain is to be developed further.—Pappas, G. D. Fine structure of host‐graft relationships between transplanted chromaffin cells and CNS.FASEB J.13 (Suppl.), S277‐S280 (1999)
