Detecting abnormalities of corpus callosum connectivity in autism using magnetic resonance imaging and diffusion tensor tractography
Detecting abnormalities of corpus callosum connectivity in autism using magnetic resonance imaging and diffusion tensor tractography
复制标题
使用磁共振成像和扩散张量纤维束成像检测自闭症患者胼胝体连接异常
DOI：
10.1016/j.pscychresns.2011.03.009
复制
发表时间：
2011-12-30
影响因子：
2.3
通讯作者：
Liu, Yijun
中科院分区：
文献类型：
--
作者：
Hong, Shanshan;Ke, Xiaoyan;Liu, Yijun
胼胝体（CC）已成为自闭症研究的主要目标之一。为了检测自闭症患者异常的 CC 半球间连接，我们对 18 名高功能自闭症 (HFA) 儿童和 16 名匹配的典型发育 (TD) 儿童进行了基于 T1 加权磁共振成像 (MRI) 和扩散张量成像 (DTI) 的纤维束成像。我们比较了两组之间的整体和区域 T1 测量（CC 体积和 CC 密度）以及 DTI 测量[分数各向异性 (FA)、表观扩散系数 (ADC)、平均纤维长度 (AFL) 和纤维数量 (FN)]。我们还评估了儿童自闭症评定量表 (CARS) 分数与 CC T1 或 DTI 测量值之间的关系。与 TO 儿童相比，HFA 患者的 CC 前三分之一白质密度显着较低，前第三经胼胝体纤维束的 ADC 较高，FN 值较低。这些结果表明，HFA 儿童的前第三 CC 密度和胼胝体纤维连接受到影响。 (C) 2010 Elsevier Ireland Ltd. 保留所有权利。
The corpus callosum (CC) has emerged as one of the primary targets of autism research. To detect aberrant CC interhemispheric connectivity in autism, we performed T1-weighted magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI)-based tractography in 18 children with high functioning autism (HFA) and 16 well-matched typically developing (TD) children. We compared global and regional T1 measures (CC volume, and CC density), and the DTI measures [fractional anisotropy (FA), apparent diffusion coefficient (ADC), average fiber length (AFL), and fiber number (FN)] of transcallosal fibers, between the two groups. We also evaluated the relationships between scores on the Childhood Autism Rating Scale (CARS) and CC T1 or DTI measurements. Significantly less white matter density in the anterior third of the CC, and higher ADC and lower FN values of the anterior third transcallosal fiber tracts were found in HFA patients compared to TO children. These results suggested that the anterior third CC density and transcallosal fiber connectivity were affected in HFA children. (C) 2010 Elsevier Ireland Ltd. All rights reserved.