Diastereoselective synthesis of pyrrolidine derivatives via a one-pot nitro-Mannich/hydroamination cascade using base and gold catalysis
Diastereoselective synthesis of pyrrolidine derivatives via a one-pot nitro-Mannich/hydroamination cascade using base and gold catalysis
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DOI：
10.1039/c3cc40729b
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发表时间：
2013-01-01
影响因子：
4.9
通讯作者：
Dixon, Darren J.
中科院分区：
文献类型：
--
作者：
Duris, Andrej;Barber, David M.;Dixon, Darren J.
报道了一种高效的一锅法硝基Mannich/氢胺化级联反应合成具有三个立构中心的取代吡咯烷。在碱和金（I）催化剂的组合的控制下进行，级联反应以高产率提供具有良好至优异的非对映选择性的吡咯烷产物。
An efficient one-pot nitro-Mannich/hydroamination cascade reaction for the synthesis of substituted pyrrolidines bearing three stereocentres is reported. Proceeding under the control of a combination of base and gold(I) catalysts, the cascade reaction affords the pyrrolidine products in high yields with good to excellent diastereoselectivities.