VINIGROL, A NOVEL ANTIHYPERTENSIVE AND PLATELET-AGGREGATION INHIBITORY AGENT PRODUCED BY A FUNGUS, VIRGARIA-NIGRA .1. TAXONOMY, FERMENTATION, ISOLATION, PHYSICOCHEMICAL AND BIOLOGICAL PROPERTIES
VINIGROL, A NOVEL ANTIHYPERTENSIVE AND PLATELET-AGGREGATION INHIBITORY AGENT PRODUCED BY A FUNGUS, VIRGARIA-NIGRA .1. TAXONOMY, FERMENTATION, ISOLATION, PHYSICOCHEMICAL AND BIOLOGICAL PROPERTIES
复制标题
DOI：
10.7164/antibiotics.41.25
复制
发表时间：
1988-01-01
影响因子：
3.3
通讯作者：
OKUHARA, M
中科院分区：
文献类型：
--
作者：
ANDO, T;TSURUMI, Y;OKUHARA, M
从培养的菌丝体中提取由一株鉴定为Virgaria nigra的真菌产生的Vinigrol，经溶剂萃取纯化，硅胶层析，分离成结晶（C20H34O3, mp 108℃）。C)。静脉给药时，维尼格罗降低了麻醉的正常血压大鼠的动脉血压。Vinigrol抑制血小板活化因子和肾上腺素诱导的血小板聚集。
Vinigrol, produced by a fungal strain identified as Virgaria nigra, was extracted from the cultured mycelium, purified by solvent extraction followed by chromatography on silica gel and then isolated as crystals (C20H34O3, mp 108.degree. C). Vinigrol decreased arterial blood pressure of anesthetized normotensive rats dose-dependently when administered intravenously. Vinigrol inhibited platelet activating factor and epinephrine induced platelet aggregation.