Platelet to lymphocyte ratio correlates with diabetic foot risk and foot ulcer in patients with type 2 diabetes
Platelet to lymphocyte ratio correlates with diabetic foot risk and foot ulcer in patients with type 2 diabetes
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DOI：
10.1507/endocrj.ej18-0477
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发表时间：
2019-01-01
影响因子：
2
通讯作者：
Fukui, Michiaki
中科院分区：
文献类型：
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作者：
Mineoka, Yusuke;Ishii, Michiyo;Fukui, Michiaki
糖尿病足溃疡是糖尿病患者的主要并发症。血小板-淋巴细胞比率（PLR）近年来被报道对糖尿病的一些并发症有预测作用。然而，尚未完全阐明2型糖尿病患者中糖尿病足风险或糖尿病足溃疡与PLR之间的关系。因此，我们的目的是评估这种关系。在这项横断面研究中，我们评估了453例连续2型糖尿病患者的糖尿病足风险与糖尿病足国际工作组（IWGDF）标准和足部溃疡流行率以及PLR之间的关系。倾向评分分析用于调整协变量的差异;年龄、性别、糖尿病病程、体重指数（HMI）、HbA 1c、当前吸烟、高血压、血脂异常、神经病变、PAD、足部畸形和足部溃疡病史。高风险糖尿病足或足溃疡患者的PLR更高（117 +/- 40 vs. 107 +/- 31，p = 0.003和148 +/- 65 vs. 113 +/- 56，p < 0.001）。受试者工作特征曲线表明，PLR为130.6构成了普遍足部溃疡的临界值，敏感性为0.85，特异性为0.70。多变量logistic回归分析显示，在用倾向评分分析调整多个变量后，PLR与足部溃疡患病率呈正相关（比值比，1.02; 95%置信区间1.01-1.04，p = 0.003）。我们的研究结果表明，PLR可以作为2型糖尿病患者中高危糖尿病足和糖尿病足溃疡的标志物。
Diabetic foot ulcer is a major complication in patients with diabetes. Platelet-lymphocyte ratio (PLR) has been reported to have a predictive effect to some diabetic complications in recent years. However, it has not been fully elucidated about the relationship between diabetic foot risk or diabetic foot ulcer and PLR in patients with type 2 diabetes. Therefore, we aimed to evaluate this relationship. In this cross-sectional study, we evaluated the relationships between patient's diabetic foot risk with the criteria of the International Working Group on the Diabetic Foot (IWGDF) and prevalent foot ulcer, and PLR in 453 consecutive patients with type 2 diabetes. Propensity score analysis was used to adjust the difference of covariates; age, sex, duration of diabetes, body mass index (HMI), HbA1c, current smoking, hypertension, dyslipidemia, neuropathy, PAD, foot deformity and history of foot ulcers. PLR was higher in patients with high risk diabetic foot or foot ulcer (117 +/- 40 vs. 107 +/- 31, p = 0.003 and 148 +/- 65 vs. 113 +/- 56, p < 0.001). A receiver-operating characteristic curve demonstrated that PLR of 130.6 constitutes the cut-off value for prevalent foot ulcer with sensitivity 0.85 and specificity 0.70. Multivariate logistic regression analysis revealed that PLR was positively correlated with prevalent foot ulcer (odds ratio, 1.02; 95% confidence interval 1.01-1.04, p = 0.003) after adjusted for several variables with propensity score analysis. Our results demonstrated that PLR can be a marker for high risk diabetic foot and diabetic foot ulcer in patients with type 2 diabetes.