Aldehyde Dehydrogenase 1 making molecular inroads into the differential vulnerability of nigrostriatal dopaminergic neuron subtypes in Parkinson's disease.
Aldehyde Dehydrogenase 1 making molecular inroads into the differential vulnerability of nigrostriatal dopaminergic neuron subtypes in Parkinson's disease.
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DOI：
10.1186/2047-9158-3-27
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发表时间：
2014
影响因子：
12.6
通讯作者：
Ding J
中科院分区：
文献类型：
--
作者：
Cai H;Liu G;Sun L;Ding J
帕金森病（PD）是最常见的退行性运动障碍，其主要的运动症状是黑质多巴胺能神经元（DA）的功能障碍/丧失。然而，神经元的损失不是随机的，而是显示区域选择性，表明在SNPC中存在不同的DA亚群。因此，确定潜在的分子决定因素有助于理解PD相关神经元功能障碍/丧失的病理生理机制，并提供新的治疗靶点。最近，我们已经证明，醛脱氢酶1（ALDH 1A 1）是这样一个分子决定因素，定义和保护SNpc DA神经元亚群优先影响PD。在这篇综述中，我们提供了进一步的分析和讨论的作用ALDH 1A 1在SNpc DA神经元的功能和生存在啮齿动物和人类的大脑。我们还探讨了ALDH 1A 1作为PD潜在生物标志物和治疗靶点的可行性。
A preferential dysfunction/loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc) accounts for the main motor symptoms of Parkinson’s disease (PD), the most common degenerative movement disorder. However, the neuronal loss is not stochastic, but rather displays regionally selectivity, indicating the existence of different DA subpopulations in the SNpc. To identify the underlying molecular determinants is thereby instrumental in understanding the pathophysiological mechanisms of PD-related neuron dysfunction/loss and offering new therapeutic targets. Recently, we have demonstrated that aldehyde dehydrogenase 1 (ALDH1A1) is one such molecular determinant that defines and protects an SNpc DA neuron subpopulation preferentially affected in PD. In this review, we provide further analysis and discussion on the roles of ALDH1A1 in the function and survival of SNpc DA neurons in both rodent and human brains. We also explore the feasibility of ALDH1A1 as a potential biomarker and therapeutic target for PD.