Emerging Role for Linear and Circular Spermine Oxidase RNAs in Skeletal Muscle Physiopathology.
Emerging Role for Linear and Circular Spermine Oxidase RNAs in Skeletal Muscle Physiopathology.
复制标题
DOI：
10.3390/ijms21218227
复制
发表时间：
2020-11-03
影响因子：
5.6
通讯作者：
Cervelli M
中科院分区：
文献类型：
--
作者：
Reinoso-Sánchez JF;Baroli G;Duranti G;Scaricamazza S;Sabatini S;Valle C;Morlando M;Casero RA Jr;Bozzoni I;Mariottini P;Ceci R;Cervelli M
Skeletal muscle atrophy is a pathological condition so far without effective treatment and poorly understood at a molecular level. Emerging evidence suggest a key role for circular RNAs (circRNA) during myogenesis and their deregulation has been reported to be associated with muscle diseases. Spermine oxidase (SMOX), a polyamine catabolic enzyme plays a critical role in muscle differentiation and the existence of a circRNA arising from SMOX gene has been recently identified. In this study, we evaluated the expression profile of circular and linear SMOX in both C2C12 differentiation and dexamethasone-induced myotubes atrophy. To validate our findings in vivo their expression levels were also tested in two murine models of amyotrophic lateral sclerosis: SOD1G93A and hFUS+/+, characterized by progressive muscle atrophy. During C2C12 differentiation, linear and circular SMOX show the same trend of expression. Interestingly, in atrophy circSMOX levels significantly increased compared to the physiological state, in both in vitro and in vivo models. Our study demonstrates that SMOX represents a new player in muscle physiopathology and provides a scientific basis for further investigation on circSMOX RNA as a possible new therapeutic target for the treatment of muscle atrophy.
登录
查看更多内容
影响因子：
14.9
作者：
Danan M;Schwartz S;Edelheit S;Sorek R
通讯作者：
Sorek R
DOI：
10.1152/ajpendo.00472.2014
发表时间：
2015-01-15
影响因子：
5.1
作者：
Bongers, Kale S.;Fox, Daniel K.;Adams, Christopher M.
通讯作者：
Adams, Christopher M.
影响因子：
3.8
作者：
Duranti, Guglielmo;Ceci, Roberta;Di Luigi, Luigi
通讯作者：
Di Luigi, Luigi
影响因子：
14.5
作者：
HAVERKAMP, LJ;APPEL, V;APPEL, SH
通讯作者：
APPEL, SH
靶向 Smox 对脑缺血/再灌注大鼠具有神经保护作用并改善脑炎症
影响因子：
3.8
作者：
Fan, Jiawei;Chen, Mei;Dai, Xiaozhen
通讯作者：
Dai, Xiaozhen